Results 41 to 50 of about 27,066 (218)

Drug‐facilitated crime: A review of findings between 2019 and 2023

Journal of Forensic Sciences, EarlyView.
Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Meaghan R. Hessler, Sherri L. Kacinko, Barry K. Logan   +2 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Rectal Thiopental versus Intramuscular Ketamine in Pediatric Procedural Sedation and Analgesia; a Randomized Clinical Trial

Emergency, 2015
Introduction: Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ...
Reza Azizkhani, Mehrdad Esmailian, Azadeh shojaei, Keihan Golshani   +3 more
doaj  

Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?

Epilepsia, Volume 66, Issue 3, Page 674-685, March 2025.
Abstract Objective Large language models (LLMs) have recently gained attention for clinical decision‐making and diagnosis. This study evaluates the performance of the recently updated LLM Chat Generative Pre‐Trained Transformer‐4omni (ChatGPT‐4o) in predicting clinical outcomes in patients with status epilepticus and compares its prognostic performance
Simon A. Amacher, Sira M. Baumann, Sebastian Berger, Armon Arpagaus, Simon B. Egli, Pascale Grzonka, Paulina S. C. Kliem, Sabina Hunziker, Urs Fisch, Caroline E. Gebhard, Raoul Sutter   +10 more
wiley   +1 more source

Optimizing phenobarbital dosing in critically ill patients with refractory and superrefractory status epilepticus using a population pharmacokinetic model

Epilepsia, EarlyView.
Abstract Objective Current weight‐based dosing fails to account for pharmacokinetic variability in refractory and superrefractory status epilepticus (RSE, SRSE). However, understanding pharmacokinetics in critically ill patients with varying degrees of organ dysfunction can improve both safety and efficacy.
Maximilian Stoschus, Moritz L. Schmidbauer, Johannes Starp, Stefan Kunst, Georgios Gakis, Michael Paal, Michael Vogeser, Christina Scharf‐Janssen, Uwe Liebchen, Konstantinos Dimitriadis   +9 more
wiley   +1 more source

Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado

Journal of Pediatric Critical Care
Background: Pediatric patients require pharmacological management of pain and agitation associated with mechanical ventilation. Pain and agitation may be refractory to opioids and alpha-2 agonists, prompting the use of adjunctive analgesics and sedatives
Kelli Jo Welter, Mackenzie N. DeVine, Sharon E. Gordon, Gina Demasellis   +3 more
doaj   +1 more source

The Value of Ultrasonography in determining Pupillary Light Reflex in Patients with Traumatic Ocular Injuries; a Letter to Editor

Archives of Academic Emergency Medicine, 2019
Pupillary light reflex (PLR) measurement is one of the frequent physical examinations used by emergency physicians for assessment of brain stem function and monitoring of intracranial pressure (1, 2).
Hamid Mirjalili, Ali Raee Ezzabadi, Yeganeh Yazdiyousefi, Mohammad Ali Jafari Nadoshan   +3 more
doaj   +1 more source

Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany

Epilepsia, EarlyView.
Abstract Objective Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep. Methods We conducted a multicenter cross‐sectional study
Johann Philipp Zöllner, Catrin Mann, Laurent Willems, Felix von Podewils, Lisa Langenbruch, Laura Bierhansl, Susanne Knake, Katja Menzler, Juliane Schulz, Bernadette Gaida, Felix Rosenow, Adam Strzelczyk   +11 more
wiley   +1 more source

Ketamine/xylazine and barbiturates modulate microglial morphology and motility differently in a mouse model.

PLoS ONE, 2020
Microglia, the resident immune cells of the brain, are highly ramified and motile and their morphology is strongly linked to their function. Microglia constantly monitor the brain parenchyma and are crucial for maintaining brain homeostasis and fine ...
Ines Hristovska, Franck Verdonk, Jean-Christophe Comte, Eileen S Tsai, Virginie Desestret, Jérôme Honnorat, Fabrice Chrétien, Olivier Pascual   +7 more
doaj   +1 more source

Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti, Alessio Passalacqua, Maria Cristina Regondi, Giada D'Ambrosio, Alessandra Morano, Michele Romoli, Giulia Maira, Flavio Villani, Pietro Mattioli, Diego Franciotta, Andrea Stabile, Marco de Curtis, Matteo Gastaldi, Francesco Deleo, Laura Librizzi   +14 more
wiley   +1 more source