Results 41 to 50 of about 66,176 (317)
British Journal of Clinical Pharmacology, EarlyView.Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside +5 more
wiley +1 more source
Too Sick to Be Executed: Shocking Punishment and the Brain [PDF]
, 2016 Capital punishment, to be lawfully delivered, must occur without needless cruelty. Cruelty, defined in the setting of punishment, will naturally evolve with the maturation of civil society.
Zivot, Joel
core +1 more source
Crystal structure of 5-hydroxy-5-propylbarbituric acid
Acta Crystallographica Section E: Crystallographic Communications, 2015 Molecules of the title compound, C7H10N2O4, systematic name 5-hydroxy-5-propylpyrimidine-2,4,6(1H,3H,5H)-trione, form a hydrogen-bonded framework which is based on three independent hydrogen bonds, N—H...O(carbonyl), N—H...O(hydroxy) and O—H...O(carbonyl)
Thomas Gelbrich, Ulrich J. Griesser
doaj +1 more source
Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics
Clinical Pharmacology in Drug Development, EarlyView.Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman +3 more
wiley +1 more source
Current Concepts on Drug Abuse and Dependence [PDF]
, 2015 Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza +5 more
core +2 more sources
Forensic Sciences Research, 2019 In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen +8 more
doaj +1 more source
Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. [PDF]
PLoS ONE, 2012 GABAergic signaling is essential for proper respiratory function. Potentiation of this signaling with allosteric modulators such as anesthetics, barbiturates, and neurosteroids can lead to respiratory arrest.
Keith B Hengen +7 more
doaj +1 more source
Case report: Fatal poisoning caused by additive effects of two barbiturates
Frontiers in Pharmacology, 2023 A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 ...
Sella Takei +9 more
doaj +1 more source
Infant Death due to Cannabis Ingestion
Drug Testing and Analysis, EarlyView.ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto +9 more
wiley +1 more source
Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Developmental Dynamics, EarlyView.Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco +8 more
wiley +1 more source