Results 51 to 60 of about 61,704 (277)

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. [PDF]

PLoS ONE, 2012
GABAergic signaling is essential for proper respiratory function. Potentiation of this signaling with allosteric modulators such as anesthetics, barbiturates, and neurosteroids can lead to respiratory arrest.
Keith B Hengen, Nathan R Nelson, Kyle M Stang, Stephen M Johnson, Stephanie M Crader, Jyoti J Watters, Gordon S Mitchell, Mary Behan   +7 more
doaj   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Rapid visualization of fingerprints on various surfaces using ZnO superstructures prepared via simple combustion route

Journal of Science: Advanced Materials and Devices, 2018
A simple solution combustion route has been used to prepare ZnO nanopowders (NPs) using different barbiturates (Barbituric acid, 1, 3-dimethyl barbiturates and 2-thiobarbiturates) as fuels.
N.H. Deepthi, R.B. Basavaraj, S.C. Sharma, J. Revathi, Ramani, S. Sreenivasa, H. Nagabhushana   +6 more
doaj   +1 more source

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration [PDF]

, 2012
Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in ...
A Agrawal, A Pierucci-Lagha, A Ruiz, AR Yang, C Fahlke, C Schwarzer, CI Dixon, CI Dixon, Claire I. Dixon, D Belelli, David N. Stephens, DM Dick, E Persohn, GJ Lydall, HH Samson, HJ Edenberg, HL June, HM Haughey, HV Morris, HV Morris, I Ponomarev, J Covault, J Lappalainen, JE Kralic, JE Kralic, JL Weiner, JT Sakai, K Low, KA Wafford, M Roberto, M Tauber, M Wakita, MA Enoch, MA Enoch, ML Barbaccia, N Onori, PA Lind, PJ Zhu, RT Khisti, Rudolph Uwe, S Bohlhalter, S Hansen, S Pirker, S Ueno, Sarah L. King, Sophie E. Walker, YA Blednov   +46 more
core   +2 more sources

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, EarlyView.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Assessment of Controlled Substance Distribution to U.S. Veterinary Teaching Institutions From 2006 to 2019

Frontiers in Veterinary Science, 2020
Objective: To evaluate the changing pattern of distribution of Schedule II and III opioids, barbiturates, and stimulants to veterinary educational institutions in the United States.Design: Longitudinal study.Sample: Veterinary teaching institutions that ...
Brian J. Piper, Brian J. Piper, Kenneth L. McCall, Lori R. Kogan, Peter Hellyer   +4 more
doaj   +1 more source

Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs

Neurobiology of Disease, 2021
Barbiturates and benzodiazepines are potent GABAA receptor agonists and strong anticonvulsants. In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long-term ...
Kevin K. Noguchi, Nicole A. Fuhler, Sophie H. Wang, Saverio Capuano, III, Kevin R. Brunner, Shreya Larson, Kristin Crosno, Heather A. Simmons, Andres F. Mejia, Lauren D. Martin, Gregory A. Dissen, Ansgar Brambrink, Chrysanthy Ikonomidou   +12 more
doaj   +1 more source

Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault

Forensic Sciences Research, 2019
In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen, Yan Shi, Xiaoguang Zhang, Bing Xie, Wenqiao Liu, Feng Yu, Ping Xiang, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Overview: eutanasia and methods of antanasia of animals

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2022
The attention of modern society to euthanasia has increased because many centuries ago, a social phenomenon was established, associated not only with the achievements of medical science but also with changing values of the individual and society ...
S. Nichiporuk, M. Radzykhovskyi, B. Gutyj   +2 more
doaj   +1 more source

Effects of gabergic phenols on the dynamic and structure of lipid bilayers: A molecular dynamic simulation approach [PDF]

, 2019
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate and invertebrate nervous system. GABAA receptors are activated by GABA and their agonists, and modulated by a wide variety of recognized drugs, including barbiturates ...
Garcia, Daniel Asmed, Miguel, Virginia, Villarreal, Marcos Ariel   +2 more
core   +2 more sources