Results 51 to 60 of about 20,745 (198)

Is Hypercortisolism Treatable? Which Patients Should Be Treated and How—A Practical Guide for Clinicians

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1‐mg dexamethasone suppression test (DST) for targeted case‐finding, and which patients are most likely to benefit from treatment.
Juan Pablo Frias
wiley   +1 more source

A patient‐centered conceptual model and measurement framework for migraine experience developed by the Migraine Clinical Outcome Assessment System

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To develop a comprehensive, evidence‐based, patient‐centered conceptual model of migraine and to derive a measurement framework for the development or selection of clinical outcome assessments used in clinical trials of treatments for migraine.
Rikki Mangrum, Alexandra L. Bryant, Carrie R. Houts, James S. McGinley, Dawn C. Buse, Richard B. Lipton, R. J. Wirth   +6 more
wiley   +1 more source

Beyond the Law: A Qualitative Socio‐Ecological Study of Substance Use Treatment Barriers and Adaptations in Ghana

Journal of Psychiatric and Mental Health Nursing, EarlyView.
ABSTRACT Background Ghana's response to substance use has long been dominated by criminalisation, yet limited research has examined how this policy environment shapes addiction treatment delivery. This study explored the perspectives of mental health nurses providing care to people who use drugs (PWUDs) using a socio‐ecological framework.
Evans F. Kyei, Dorothy Wilson, Grace K. Kyei, Rockson Ansong, Mercy N. Mumba   +4 more
wiley   +1 more source

Modified Manual Therapeutic Plasma Exchange Technique as a Successful Treatment for Postattenuation Neurological Signs (PANS) in a Dog

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To investigate and describe the therapeutic potential of manual plasma exchange for controlling seizures and neurologic dysfunction in a dog with postattenuation neurologic signs (PANS). Case Summary A 4‐year‐old neutered female Yorkshire Terrier was initially diagnosed using computed tomography with a congenital extrahepatic ...
Marcos Fumero‐Hernández, Marta Ribas, Patricia Bou, Carlos Torrente, Luis Bosch   +4 more
wiley   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans

Experimental Physiology, EarlyView.
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin, Jean‐Christophe Lagacé, Mathil Ruel, Ahmed Ghachem, Guillaume Léonard, Eleonor Riesco, Mathew Piasecki, Jamie S. McPhee, Isabelle J. Dionne   +8 more
wiley   +1 more source

Association Between Spinal Manipulation, Butalbital Prescription, and Medication Overuse Headache in Adults With Tension‐Type Headache: Retrospective Cohort Study

Health Science Reports
Background and Aims Butalbital is an acute headache medication commonly prescribed for tension‐type headache (TTH), although discouraged by guidelines due to a risk of medication overuse headache (MOH).
Robert J. Trager, Timothy J. Williamson, Pratheek S. Makineni, Lindsay H. Morris   +3 more
doaj   +1 more source

Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives

Journal of Chemistry, 2016
A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood   +9 more
doaj   +1 more source

Distinctive neurophysiological correlates of sound onset and offset perception in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Electroencephalography (EEG) recordings were obtained from participants listening to successive pairs of 1‐2 s noises in a silent background (Study 1) or successive pairs 1‐2 s silent gaps in a noise background (Study 2). Participants heard the same stimuli in the context of either a duration discrimination task (identifying ...
Fatima Ali, Gabriela Bury, Adèle Simon, Jennifer F. Linden   +3 more
wiley   +1 more source

Evolution of Pharmacologic Induction of Burst Suppression in Adult TBI: Barbiturate Coma Versus Modern Sedatives

Clinical and Translational Neuroscience
Background: Severe traumatic brain injury (TBI) often leads to elevated intracranial pressure (ICP) that requires aggressive management. Inducing burst suppression with deep sedation is an established therapy for refractory intracranial hypertension ...
Đula Đilvesi, Teodora Tubić, Sanja Maričić Prijić, Jagoš Golubović   +3 more
doaj   +1 more source