Results 71 to 80 of about 22,960 (244)
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans
Experimental Physiology, EarlyView.Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin +8 more
wiley +1 more source
The Role of Barbiturates for Alcohol Withdrawal Syndrome.
, 2016 BACKGROUND: Benzodiazepine-resistant cases of alcohol withdrawal syndrome are common, and therefore alternate treatments are needed. OBJECTIVE: Our aim was to conduct a systematic review of published reports on the use of barbiturates for alcohol ...
Martin, Katherine B., MD, Katz, Andrew
core
The Journal of Physiology, EarlyView.Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite +9 more
wiley +1 more source
Barbiturates are selective antagonists at A\(_1\) adenosine receptors
, 1985 Barbiturates in pharmacologically relevant . concentrations inhibit binding of (R)-\(N^6\)-phenylisopropyl[\(^3\)H]adenosine ([\(^3\)H]PIA) to solubilized A\(_1\) adenosine receptors in a concentration-dependent, stereospecific, and competitive manner. K\
Schwabe, U. +3 more
core
Journal of Chemistry, 2016 A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat +9 more
doaj +1 more source
Distinctive neurophysiological correlates of sound onset and offset perception in humans
The Journal of Physiology, EarlyView.Abstract figure legend Electroencephalography (EEG) recordings were obtained from participants listening to successive pairs of 1‐2 s noises in a silent background (Study 1) or successive pairs 1‐2 s silent gaps in a noise background (Study 2). Participants heard the same stimuli in the context of either a duration discrimination task (identifying ...
Fatima Ali +3 more
wiley +1 more source
Analysis of Barbiturates by GC/MS, HPLC and Chemical Ionization
, 2012 Barbiturates are derivatives of barbituric acid. They act as central nervous depressants. These drugs are frequently used as sedatives or anesthetics. It is a simple and reproducible method for the analysis of barbiturates.
Ravipati, Deepthi
core
Multicomponent, One-Pot Sequential Synthesis of 1,3,5- and 1,3,5,5-Substituted Barbiturates
, 2016 Carbodiimides and malonic acid monoethylesters readily react to afford N-acylurea derivatives that could be cyclized in situ by addition of a suitable base.
Alessandro Volonterio (172619) +1 more
core +1 more source
Health Science ReportsBackground and Aims Butalbital is an acute headache medication commonly prescribed for tension‐type headache (TTH), although discouraged by guidelines due to a risk of medication overuse headache (MOH).
Robert J. Trager +3 more
doaj +1 more source
Drug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang +3 more
wiley +1 more source