Results 81 to 90 of about 22,960 (244)

Application of thermoresponsive HPLC to forensic toxicology: determination of barbiturates in human urine [PDF]

, 2009
A high-performance liquid chromatography (HPLC) method has been developed for the assays of five barbiturates in human urine using a new thermoresponsive polymer separation column, which is composed of N-isopropylacrylamide polymer.
Minakata, Kayoko, Watanabe, Kanako, Hirano, Seishiro, Yamagishi, Itaru, Suzuki, Osamu, Gonmori, Kunio, Kanno, Sanae   +6 more
core   +1 more source

Evolution of Pharmacologic Induction of Burst Suppression in Adult TBI: Barbiturate Coma Versus Modern Sedatives

Clinical and Translational Neuroscience
Background: Severe traumatic brain injury (TBI) often leads to elevated intracranial pressure (ICP) that requires aggressive management. Inducing burst suppression with deep sedation is an established therapy for refractory intracranial hypertension ...
Đula Đilvesi, Teodora Tubić, Sanja Maričić Prijić, Jagoš Golubović   +3 more
doaj   +1 more source

Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database

Journal of Epidemiology, 2017
Background: Little is known about the nationwide epidemiology of the annual rate, causative substance, and clinical course of overdose-related admission.
Yasuyuki Okumura
doaj   +1 more source

Protocol‐Based Management of Medication Confounders in Brain Death Determination: A Multi‐Institutional Review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 7, July 2026.
ABSTRACT Background Determination of death by neurologic criteria (DNC) relies on clinical examination, provided no confounding conditions affect reliability. Current guidelines require patients to be free of confounders before neurologic testing but do not specify how these confounders should be assessed or managed.
Alexander Nixon, Jeffrey Mucksavage, Chris Morrison, Nicholas G. Panos, Katleen Chester, Sherif Hanafy Mahmoud, Devin Holden, Casey C. May   +7 more
wiley   +1 more source

Chromatographic descriptors in QSAR study of barbiturates

, 2019
Barbiturate derivatives were evaluated for their parameters of biological activity by applying linear regression and two multivariate methods (Cluster analysis and Principal component analysis).
Vastag, Gyoengyi, Mrdjan, Gorana, Apostolov, Suzana, Stojiljković, Ivana, Nakomcić, Jelena   +4 more
core   +1 more source

Integration of thin layer chromatography and smartphone-based colorimetric analysis for the detection of barbiturates

Green Analytical Chemistry
Barbiturates, a key class of psychoactive drugs, present challenges in accurate detection due to their misuse and involvement in forensic investigations.
Keneuoe Letumanyane, Elisa Kalugendo
doaj   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Health, Social and Recidivism Outcomes Among People Who Have Been Incarcerated in New South Wales, Australia: Study Protocol and Cohort Profile for the Prison Outcomes STudy (POST)

Drug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Introduction We have been funded to examine post‐incarceration health and social outcomes for all people incarcerated in New South Wales, Australia, 2000–2022; assess treatment and services for drug dependence and serious mental illness; and project the impact of expanding intervention coverage. We will use a linked cohort, the Prison Outcomes
Louisa Degenhardt, Michael Farrell, Michael Doyle, Jack Stone, Chrianna Bharat, Matt Hickman, Marianne Martinello, Don Weatherburn, Kimberlie Dean, Joe Coyte, Christel Macdonald, Mary Ellen Harrod, Luke Grant, Gloria Larman, Peter Vickerman, Colette McGrath, Peter Thompson, Alison Churchill, Greg Dore, Thomas Santo Jr   +19 more
wiley   +1 more source

Identification of Barbiturates [PDF]

Nature, 1959
IN Great Britain the most common poisons at the present time are the 5 : 5′ disubstituted barbiturates. The longer-acting barbiturates, barbitone and phenobarbitone, can accumulate in the body when administered in relatively low therapeutic dosage, and concentrations of these drugs in the blood of about 5 mgm./100 ml. do not necessarily imply poisoning.
openaire   +2 more sources

Isotellurourea‐Catalyzed Enantioselective (4+2)‐Heterocycloadditions of But‐2‐ynoates and Michael Acceptors

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Isotelluroureas allow for the use of alkynoates for asymmetric (4+2)‐heterocycloadditions with different Michael acceptors. Alk‐2‐ynoates are readily available starting materials which, in principle, can be utilized for cycloadditions in analogy to structurally similar allenoates.
Anna Scheucher, Mario Waser
wiley   +1 more source