Results 91 to 100 of about 22,960 (244)

Attempted suicide with barbiturates purchased online

, 2016
BACKGROUND: Barbiturate intoxication is potentially lethal. With the availability of the newer anticonvulsants the use of barbiturates in treating epilepsy has decreased significantly, with a concurrent decrease in the incidence of overdose with these ...
Chavoushi, S. Färaz, Mesman, Linda, Sikma, Maaike A., Noordzij, Peter G., Van Maarseveen, Erik M.   +4 more
core  

TISSUE-LIPID SOLUBILITY AND "ADSORPTION" OF BARBITURATES

, 1959
Since the barbiturates comprise one of the most widely used drug groups in modern therapy, their mode of action is of considerable interest and importance.
Irwin, William Cantlon
core   +1 more source

The psychological wellbeing of Iranian journalists: a descriptive study

JRSM Open, 2016
Objective Iran ranks 173 out of 180 countries on an index of press freedom. The purpose of the study was to assess the psychological wellbeing of Iranian journalists and document the stressors encountered in their work.
Anthony Feinstein, Saul Feinstein, Maziar Behari, Bennis Pavisian   +3 more
doaj   +1 more source

Synthesis of Levoglucosenone‐Based Amphiphilic Molecules via Microwave‐Assisted Michael Additions

Chemistry–Methods, Volume 6, Issue 6, June 2026.
Comparison between the conventional and the sustainable synthetic microwave‐based approach for Michael addition reactions on LGO developed in this work. Aligning with the objectives of the EU chemicals strategy for sustainability, an ultrarapid, safe and sustainable method for producing a library of levoglucosenone (LGO)‐based amphiphilic molecules was
Maria Jose Calandri, Barbara Benedetti, Léa Charrier, Dinis O. Abranches, James R. Sherwood, Gareth O. Lloyd, João A. P. Coutinho, Con Robert McElroy, Alessandro Pellis   +8 more
wiley   +1 more source

High dose barbiturates in non-traumatic brain swelling: ICP reduction and effect on outcome.

, 1982
High dose barbiturates were used to treat intracranial hypertension in 15 patients with nontraumatic brain lesions; (3 hypertensive hemorrhage, 4 subarachnoid hemorrhage, 5 infarction, 2 global anoxia-ischemia and 2 encephalitis).
S K Kennedy, J Woodcock, A H Ropper
core   +1 more source

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang, Weili Li, Di Wu, Shuaili Xu, Xunming Ji   +4 more
wiley   +1 more source

Takotsubo Cardiomyopathy as an Early Complication of Drug-Induced Suicide Attempt

Case Reports in Medicine, 2013
Takotsubo cardiomyopathy typically presents in menopausal women following episodes of intense physical or mental stress. To our knowledge, the literature contains only two documented cases of Takotsubo cardiomyopathy arising following a suicide attempt ...
Massimo Romanò, Federica Zorzoli, Roberta Bertona, Rosvaldo Villani   +3 more
doaj   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, Volume 11, Issue 3, Page 847-858, June 2026.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State

, 2017
International audienceBarbiturates induce anesthesia by modulating the activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs). Despite more than a century of use in clinical practice, the prototypic binding site for this class of ...
Fourati, Zaineb, Laverty, Duncan, Delarue, Sandrine, Drège, Emmanuelle, Ruza, Reinis Reinholds, Joseph, Delphine, Smart, Trevor, Delarue, Marc, Koehl, Patrice   +8 more
core   +1 more source

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source