Results 51 to 60 of about 27,317 (231)

Ketamine/xylazine and barbiturates modulate microglial morphology and motility differently in a mouse model.

PLoS ONE, 2020
Microglia, the resident immune cells of the brain, are highly ramified and motile and their morphology is strongly linked to their function. Microglia constantly monitor the brain parenchyma and are crucial for maintaining brain homeostasis and fine ...
Ines Hristovska, Franck Verdonk, Jean-Christophe Comte, Eileen S Tsai, Virginie Desestret, Jérôme Honnorat, Fabrice Chrétien, Olivier Pascual   +7 more
doaj   +1 more source

Reduction of opioid and barbiturate use following initiation of rimegepant for migraine in the United States

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen, Aaron Jenkins, Karin Hygge Blakeman, Feng Dai, Lucy Abraham, Chelsea Leroue, Josh Brown   +6 more
wiley   +1 more source

Vaporized cannabis versus placebo for acute migraine: A randomized, double‐blind, placebo‐controlled crossover trial

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the efficacy of cannabis for the treatment of acute migraine. Background Preclinical and retrospective studies suggest cannabinoids may be effective in migraine treatment. However, there have been no randomized clinical trials examining the efficacy of cannabinoids for acute migraine.
Nathaniel M. Schuster, Mark S. Wallace, Thomas D. Marcotte, Dawn C. Buse, Euyhyun Lee, Lin Liu, Michelle Sexton   +6 more
wiley   +1 more source

New‐Onset Psychosis in a Person with Parkinson's Disease after “Horny Goat Weed” Use

Movement Disorders Clinical Practice, EarlyView.
Juan R. Deliz, Kasra Manoocheri, Danielle N. Larson, Danny Bega   +3 more
wiley   +1 more source

Self‐Adhesive Flowable Resin Composites—Are We Going Somewhere?

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To map laboratory/clinical evidence on self‐adhesive flowable resin composites (SAFRCs), tracing their chemical evolution, performance, and behavior, and to identify gaps that must be addressed to drive their optimization. Overview A comprehensive literature search was performed in PubMed/MEDLINE, Scopus, and LILACS without language ...
António H. S. Delgado, Miguel Alves, Inês Pires, Marta Nunes Ferreira, Carlos Enrique Cuevas‐Suárez   +4 more
wiley   +1 more source

The Number of Newly Dispensed Hypnotic Drugs During the First COVID‐19 Lockdown Period in The Netherlands

Journal of Sleep Research, EarlyView.
ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf, Pantea Kiani, Maureen N. Zijlstra, Pauline A. Hendriksen, Johan Garssen, Joris C. Verster   +5 more
wiley   +1 more source

Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database

Journal of Epidemiology, 2017
Background: Little is known about the nationwide epidemiology of the annual rate, causative substance, and clinical course of overdose-related admission.
Yasuyuki Okumura
doaj   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives

Journal of Chemistry, 2016
A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood   +9 more
doaj   +1 more source

Association Between Spinal Manipulation, Butalbital Prescription, and Medication Overuse Headache in Adults With Tension‐Type Headache: Retrospective Cohort Study

Health Science Reports
Background and Aims Butalbital is an acute headache medication commonly prescribed for tension‐type headache (TTH), although discouraged by guidelines due to a risk of medication overuse headache (MOH).
Robert J. Trager, Timothy J. Williamson, Pratheek S. Makineni, Lindsay H. Morris   +3 more
doaj   +1 more source