Results 101 to 110 of about 3,484,802 (301)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effect of edge transmission and elastic scattering on the resistance of magnetic barriers

, 2007
Strong magnetic barriers are defined in two-dimensional electron gases by magnetizing dysprosium ferromagnetic platelets on top of a Ga[Al]As heterostructure. A small resistance across the barrier is observed even deep inside the closed regime.
B. L. Gallagher, J. Hong, M. Cerchez, N. Schulz, S. Hugger, T. Heinzel   +5 more
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Paradoxes sur le public.

EspacesTemps.net, 2007
L’État contemporain ne se rapporte pas aux citoyens de manière individualisée et concrète, il les convoque plutôt comme une masse formelle et dépersonnalisée. Par une instrumentalisation de la culture et des arts, il en fait des consommateurs d’œuvres et
Thibaut Barrier
doaj  

Understanding fluctuating climate change risk perceptions through the lens of trust: a study of Great Barrier Reef region residents

npj Climate Action
Public perceptions of climate change risks are fundamental to public support for climate action. From a decade of surveying residents in the Great Barrier Reef region (2013–2023; n = 9920), we found that climate risk perceptions have fluctuated markedly,
Elizabeth V. Hobman, Matthew I. Curnock, Michelle Dyer, Cindy Huchery, Petina L. Pert, Emilee Chamberland, Aditi Mankad   +6 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Fluids and Barriers of the CNS
Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo Kp,uu,brain estimates are the gold standard for investigating brain drug disposition, animal usage is a limitation to
Kristine Langthaler, Christopher R. Jones, Lasse Saaby, Christoffer Bundgaard, Birger Brodin   +4 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Shoulder–Elbow Joint Angle Prediction Using COANN with Multi-Source Information Integration

Applied Sciences
To address the precision challenges in upper-limb joint motion prediction, this study proposes a novel artificial neural network (COANN) enhanced by the Cheetah Optimization Algorithm (COA).
Siyu Zong, Wei Li, Dawen Sun, Zhuoda Jia, Zhengwei Yue   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source