Results 101 to 110 of about 13,899,917 (351)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

AMP-activated protein kinase: a therapeutic target in intestinal diseases [PDF]

Open Biology, 2017
Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders.
Xiaofei Sun, Mei-Jun Zhu
doaj   +1 more source

Two electrons in a strongly coupled double quantum dot: from an artificial helium atom to a hydrogen molecule

, 2005
We study the formation of molecular states in a two-electron quantum dot as a function of the barrier potential dividing the dot. The increasing barrier potential drives the two electron system from an artificial helium atom to an artificial hydrogen ...
C. G. Darwin, C. Yannouleas, H. A. Bethe, J. M. Elzerman, L. Jacak, M. Read, M. Taut, M. Wagner, P. Hawrylak, W. Dybalski, W. G. van der Wiel   +10 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Fusion of radioactive $^{132}$Sn with $^{64}$Ni

, 2007
Evaporation residue and fission cross sections of radioactive $^{132}$Sn on $^{64}$Ni were measured near the Coulomb barrier. A large sub-barrier fusion enhancement was observed.
A. Galindo-Uribarri, A. L. Caraley, C. J. Gross, D. Peterson, D. Shapira, D. W. Stracener, F. James, H. Amro, J. D. Bierman, J. F. Liang, J. Gomez del Campo, J. J. Kolata, J. R. Beene, K. L. Jones, P. A. Hausladen, P. E. Mueller, R. A. Broglia, R. L. Varner, R. Vandenbosch, W. D. Myers, W. Loveland, Y. Larochelle   +21 more
core   +1 more source

Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function

International Journal of Molecular Sciences, 2019
Mycotoxins, which are widely found in feed ingredients and human food, can exert harmful effects on animals and pose a serious threat to human health. As the first barrier against external pollutants, the intestinal mucosa is protected by a mechanical ...
Z. Ren, Chaoyue Guo, Shumin Yu, Ling Zhu, Ya Wang, Hui Hu, J. Deng   +6 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Scattering and delay time for 1D asymmetric potentials: the step-linear and the step-exponential cases

, 2016
We analyze the quantum-mechanical behavior of a system described by a one-dimensional asymmetric potential constituted by a step plus (i) a linear barrier or (ii) an exponential barrier.
Abramowitz M., Asorey M., Caldirola P., Cariñena J.F., Fabijonas B.R., Griffiths D.J., Hochstadt H., Rizzi L., Tricomi F.G., Vallée O., Watson G.N.   +10 more
core   +1 more source