Results 121 to 130 of about 6,511,959 (301)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Chapter 19: Vulnerability of coastal and estuarine habitats in the Great Barrier Reef to climate change [PDF]

, 2007
This chapter attempts to address the vulnerability of the CEM in the Great Barrier Reef region to global climate change. It does not consider individual habitats (eg reefs or seagrasses) but goes beyond the individual species and habitat assessments ...
Brodie, J.E., Brooke, B., Dale, P., Waycott, M., Sheaves, M., Lovelock, C.E., Johnston, R., Baker, R., Gehrke, P.   +8 more
core  

Application of Artificial Intelligence-Powered Research in Gastrointestinal Pathophysiology: Unveiling Intestinal Pathobionts and Microbiota Dysbiosis

Journal of Physiological Investigation
Emerging evidence indicates a critical role of an imbalanced microbiota ecosystem in the development of human diseases. The presence of decreased beneficial microbes and increased harmful bacteria is widely accepted as one of the etiologies of intestinal
Yu-Chen Pai, Linda Chia-Hui Yu
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

An In vivo Comparison of Biomimetic vs. Traditional Skin Moisturization [PDF]

, 2015
The aim of this study was to determine whether a biomimetic cream can deliver superior moisturisation to the skin of human volunteers aged over 60, compared to the effects of a conventional moisturiser containing high levels of petrolatum and mineral oil.
Kurimo, Ritva, Grant-Ross, Peter, Todorova, Petya, Tamburic, Slobodanka   +3 more
core   +1 more source

Linarin alleviates colonic barrier dysfunction induced by enterotoxic Escherichia coli in weaned piglets by regulating the gut microbiota and metabolic pathways

Frontiers in Immunology
IntroductionEnterotoxigenic Escherichia coli (ETEC) is a globally recognized gastrointestinal pathogen and a major cause of diarrhea in neonatal and post‐weaning animals, leading to significant economic losses in pig production.
Qianqian Zhang, Xiaodan Liu, Chaofan Sun, Mingyang Wang, Xu Ji, Shenghe Li, Shenghe Li, Erhui Jin, Erhui Jin, Feng Zhang, Feng Zhang   +10 more
doaj   +1 more source

ResTORing barrier function in the skin [PDF]

Journal of Allergy and Clinical Immunology, 2020
Jocelyn Wang, Mark H. Kaplan, Kai Yang
openaire   +2 more sources

Matrix Control Barrier Functions

IEEE Transactions on Automatic Control
This paper generalizes the control barrier function framework by replacing scalar-valued functions with matrix-valued ones. Specifically, we develop barrier conditions for safe sets defined by matrix inequalities -- both semidefinite and indefinite. Matrix inequalities can be used to describe a richer class of safe sets, including nonsmooth ones.
Pio Ong, Yicheng Xu, Ryan M. Bena, Faryar Jabbari, Aaron D. Ames   +4 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An account of the present knowledge and use of the Great Barrier Reef from Lizard Island to Bowen with recommendations for its conservation and management. [PDF]

, 1979

core   +1 more source