Results 111 to 120 of about 6,511,959 (301)
Veterinary SciencesThis study investigates whether fecal microbiota transplantation (FMT) can alleviate gut microbiota dysbiosis induced by a high-fat diet (HFD) through modulation of fatty acid metabolism, competition for nutrients, production of short-chain fatty acids ...
Xinyu Cao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CosmeticsNatural ingredients with soothing and skin-protecting effects are becoming increasingly popular in cosmetic science. Great interest has been directed to birch sap, a nutrient-rich fluid from Betula species.
Chao-Hsien Sung +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finite-Time Prescribed Performance Control of Nonlinear Systems With Unmeasurable States
IEEE AccessThis paper explores the finite-time prescribed performance control method for strict-feedback nonlinear systems possessing unmeasurable states. Firstly, a fuzzy observer is designed for the purpose of estimating states that are not directly accessible ...
Wenyu Zhao, Lijie Wang, Ruibin Zhu
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Barrier function and microbiotic dysbiosis in atopic dermatitis
, 2015 Sophie Seite,1 Thomas Bieber2 1La Roche-Posay Dermatological Laboratories, Asnières, France; 2Department of Dermatology and Allergy, Friedrich-Wilhelms-University, Bonn, GermanyAbstract: Atopic dermatitis (AD) or atopic eczema is the common ...
Seite S, Bieber T
core
Immunology and Barrier Function of the Skin
, 2012 A disturbed epidermal barrier may lead to irritant contact dermatitis. An enhanced penetration through skin barrier may facilitate sensitization. Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Type IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate ...
Rustemeyer, Thomas, Fartasch, Manigé
openaire +4 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Dairy Science: This study evaluated the effects of feeding a probiotic-postbiotic blend on DMI, milk and milk component yields, systemic inflammation, and regional paracellular permeability of the gastrointestinal tract (GIT) before and after exposure to an ...
C.A. Bertens +5 more
doaj +1 more source