Results 71 to 80 of about 6,511,959 (301)

Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway

Toxins, 2011
Systemic anthrax disease is characterized by vascular leakage pathologies. We previously reported that anthrax lethal toxin (LT) induces human endothelial barrier dysfunction in a cell death-independent manner with actin stress fiber formation and ...
Jason M. Warfel, Felice D’Agnillo
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2008
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Fruttiger, Marcus, Hartwig Wolburg, Babbage, J., M. Corada, Taddei, A., Monica Corada, Babbage, Jane, Wolburg, Hartwig, Corada, M., Makoto M. Taketo, Plate, Karl, A. Felici, Wolburg, H., C. J. Czupalla, Karl Heinz Plate, Harald von Melchner, Reis, M., E. Dejana, Gerhardt, Holger, Elisabetta Dejana, Marcus Fruttiger, M. Fruttiger, Dejana, Elisabetta, Angelina Felici, Jane Babbage, Taddei, Andrea, Liebner, S., Taketo, Makoto Mark, Felici, A., Liebner, Stefan, K. H. Plate, Reis, Marco, Bangsow, T., Dejana, E., M. Reis, Marco Reis, Czupalla, C.J., T. Bangsow, Cathrin J. Czupalla, A. Taddei, Felici, Angelina, H. von Melchner, Andrea Taddei, H. Wolburg, Taketo, M.M., von Melchner, H., J. Babbage, H. Gerhardt, Plate, K.H., Corada, Monica, M. M. Taketo, Czupalla, Cathrin Jacqueline, Holger Gerhardt, Stefan Liebner, S. Liebner, Fruttiger, M., Gerhardt, H., Bangsow, Thorsten, Melchner, Harald von (Prof. Dr.), Thorsten Bangsow   +59 more
core   +1 more source

Chapter 13: Vulnerability of chondrichthyan fishes of the Great Barrier Reef to climate change [PDF]

, 2007
This chapter addresses the potential impact of climate change on the chondrichthyan fauna of the Great Barrier Reef, that is, the sharks, rays, skates and holocephalans that occur within the Great Barrier Reef region.
Kyne, P.M., Chin, A.
core   +1 more source

Lipids and barrier function of the skin

Acta Dermato-Venereologica, 2000
The purpose of the present manuscript is to review the chemical and physical properties of epidermal lipids and to relate these properties to the formation and function of the permeability barrier of the skin. Lipids accumulate in small organelles known as lamellar granules as epidermal keratinocytes differentiate.
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source