Results 121 to 130 of about 4,060,901 (362)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cardiovascular Events and Heart Failure in Patients With Type 2 Diabetes Treated With Dipeptidyl Peptidase-4 Inhibitors: A Meta-Analysis

Current Therapeutic Research
Background: The global prevalence of type 2 diabetes mellitus (T2DM) continues to rise, with patients facing significantly elevated risks of cardiovascular complications, particularly heart failure (HF). Objective: This examination sought to methodically
Adili Tuersun, PhD, Shufen Cui, BS, Li Han, BS, Alimu Aikebaier, BS, Yanyan Shi, BS, Gang Cheng, PhD, Lei Cheng, BS, Guo Ma, PhD   +7 more
doaj   +1 more source

Optical Emission Spectroscopy Diagnosis on Decomposition of NO in NO/N2 Mixtures in Dielectric Barrier Discharge Plasma [PDF]

, 2005
Jing Liu, NIU Jin-Hai, Yong Xu, Ai‐Min Zhu, Qi Sun, NIE Long-Hui   +5 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Maternal education and child immunization: the mediating roles of maternal literacy and socioeconomic status

The Pan African Medical Journal, 2017
Introduction: previous studies in Nigeria have documented significant association between maternal education and child immunization. However, little is known about the pathway through which maternal education improves immunization uptake. This study aims
Saliu Adejumobi Balogun, Hakeem Abiola Yusuff, Kehinde Quasim Yusuf, Abdulah Mohammed Al-Shenqiti, Mariam Temitope Balogun, Prudence Tettey   +5 more
doaj   +1 more source

Barrier height of Re and Os contacts to n-silicon [PDF]

, 1980
A. Smirnov, P.A. Tove, Jorge de Sousa Pires, H. Norde   +3 more
openalex   +1 more source

Visible and Invisible Barriers: Evidence from Foreign Joint Venture and Domestic Brokerage Financial Analysts in China. [PDF]

, 2020
Yu Ting Forester Wong
openalex   +1 more source

Barriers to European bioenergy expansion [PDF]

, 2009
The European Commission has set challenging targets for renewable energy expansion in Europe as part of its strategy to limit greenhouse gas emissions.
Prins, Wolter, Thornley, Patricia
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Intratympanic dexamethasone microcrystal-loaded porous PLGA microspheres containing lipoic acid for combined delivery to the inner ear

Journal of Otology
Objective To develop a sustained-release codelivery system for intratympanic administration of dexamethasone (DEX) and lipoic acid (LA). Methods DEX microcrystals (MCs) were prepared via precipitation, while LA-loaded porous PLGA microspheres (LPMPs ...
Peili Zhang, Dongcheng Wang, Xin Zhang, Zongyi Wu, Zhimin Zhou, Jingjie Wang, Jianjun Sun, Mingfang Diao   +7 more
doaj   +1 more source