Results 121 to 130 of about 2,091,453 (310)

Intranasal gold nanoparticle-antigen induces mucosal and systemic immunity against β-coronaviruses

hLife
The continued emergence of diverse beta-coronaviruses (β-CoVs) from animal reservoirs underscores the urgent need for broad-spectrum mucosal vaccines, yet their development is hindered by physiological barriers, rapid antigen clearance, and suboptimal ...
Muzhuo Wang, Weijie Wang, Wei Xu, Zhikai Chen, Junlan Zhang, Zeya Li, Jiadong Li, Shibo Jiang, Lu Lu, Zezhong Liu   +9 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Natural and engineered clay barriers /

Clays are used as barriers for the isolation of landfills and contaminated sites. They are envisioned as long-term storage media for hazardous materials and radioactive wastes, and as seals in the case of geological CO2 sequestration or energy storage ...
Steefel, Carl I.,editor., Bourg, Ian C.,editor., Tournassat, Christophe,editor., Bergaya, Faïza,editor.   +3 more
core  

The Quality Control of Micro- and Nanomedicines: Compliance with Regulatory Guidelines

Pharmaceutical Fronts
Carrier-based micro- and nanomedicines, such as microspheres, liposomes, and micelles, offer enhanced benefits over traditional medications, including improved bioavailability, targeted delivery, and reduced toxicity.
Lu Li, Wei Wu, Jian Le, Yi Lu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Barriers to social enterprise growth [PDF]

, 2019
This study investigates barriers to social enterprise growth. The research employs qualitative case study data gathered from young social enterprises to examine the interplay between social enterprise and individual, organizational and institutional ...
Haugh, Helen, Chambers, Liudmila, Davies, Iain Andrew   +2 more
core  

Analysis of intratumoural bacteria: Opportunities and challenges for cancer therapy

Acta Pharmaceutica Sinica B
Intratumoural bacteria have been shown to play conflicting roles within tumours, especially in the modulation of immune responses. Moreover, bacteria have been linked to a variety of cancer types and have different prognostic values depending on the ...
Xiaowen Jiang, Chunyan Zhang, Simeng Cao, Yeheng Peng, Mingyi Zhao, Xuyao Zhang, Yuan Gao   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits

Nature Communications
Central nervous system (CNS) injury is a leading cause of death and long-term disability worldwide. Neurological deficits reflect disruption of central neural circuits.
Shiqiang Tong, Shuai Ye, Fenfen Ma, Xiaoying Xie, Yinzhe Sun, Chuchu Ma, Tiantian Shi, Zheng Cheng, Chang Li, Weili Han, Laozhi Xie, Songlei Zhou, Jianing Gong, Chen Huang, Yukun Huang, Gan Jiang, Xiaolin Liu, Bing Li, Feng Zeng, Jingru Gong, Zhihua Wang, Xiaoling Gao, Qiyong Mei, Wei-Guang Li, Jun Chen   +24 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source