Results 101 to 110 of about 2,091,453 (310)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Canadian non-tariff barriers to trade

, 1973
The table of contents for this item can be shared with the requester. The requester may then choose one chapter, up to 10% of the item, as per the Fair Dealing provision of the Canadian Copyright ActIDRC supported.
Stegemann, K., C. D. Howe Research Institute, Pestieau, C.   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Cardiovascular Events and Heart Failure in Patients With Type 2 Diabetes Treated With Dipeptidyl Peptidase-4 Inhibitors: A Meta-Analysis

Current Therapeutic Research
Background: The global prevalence of type 2 diabetes mellitus (T2DM) continues to rise, with patients facing significantly elevated risks of cardiovascular complications, particularly heart failure (HF). Objective: This examination sought to methodically
Adili Tuersun, PhD, Shufen Cui, BS, Li Han, BS, Alimu Aikebaier, BS, Yanyan Shi, BS, Gang Cheng, PhD, Lei Cheng, BS, Guo Ma, PhD   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Intratympanic dexamethasone microcrystal-loaded porous PLGA microspheres containing lipoic acid for combined delivery to the inner ear

Journal of Otology
Objective To develop a sustained-release codelivery system for intratympanic administration of dexamethasone (DEX) and lipoic acid (LA). Methods DEX microcrystals (MCs) were prepared via precipitation, while LA-loaded porous PLGA microspheres (LPMPs ...
Peili Zhang, Dongcheng Wang, Xin Zhang, Zongyi Wu, Zhimin Zhou, Jingjie Wang, Jianjun Sun, Mingfang Diao   +7 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Effects of Tariffs and Sanitary Barriers on High- and Low-Value Poultry Trade [PDF]

A competitive partial-equilibrium spatial model with heterogeneous goods is constructed to evaluate effects of the removal of tariffs, tariff-rate quotas, and sanitary regulations on world poultry trade.
Orden, David, Peterson, Everett B.
core  

Internationalization of Lithuanian SMEs: Investigation of Barriers and Motives

The presented paper aims to reveal internationalization barriers and motives of Lithuanian small and medium size enterprises (SMEs). The perceptions of internationalized and non-internationalized firms were assessed.
Korsakiene, Renata
core   +1 more source

Revisiting endothelial tropism of SARS-CoV-2 using a cell-specific hACE2 mouse model

Microbiology Spectrum
Severe COVID-19 is frequently associated with vascular complications, raising ongoing debate about whether SARS-CoV-2 can directly infect endothelial cells and thereby contribute to disease pathogenesis.
Sahine Lameire, Nincy Debeuf, Julie Deckers, Caroline De Wolf, Manon Vanheerswynghels, Wendy Toussaint, Lize De Vlieger, Lien Van Hoecke, Arnout Bruggeman, Sieglinde De Cae, Bert Schepens, Stijn Vanhee, Bart N. Lambrecht   +12 more
doaj   +1 more source