Results 41 to 50 of about 3,618,266 (313)
Formation of tissue barriers starts in early development where it is critical for normal cell fate selection, differentiation and organogenesis. Barrier maintenance is critical to the ongoing function of organs during adulthood and aging. Dysfunctional tissue barrier formation and function at any stage of the organismal life cycle underlies many ...
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin +2 more
doaj +1 more source
Knowledge, attitude, and barriers toward polio immunization among pre-clinical students in Malaysia
Background: Polio is reported as reemerging disease in Malaysia after 27 years of being free from it. It is important to identify the awareness towards polio vaccine among the medical students who are the future and the pillars of the nation, to develop ...
Theingi Maung Maung +7 more
doaj +1 more source
Overcoming Barriers in Communities [PDF]
Panelist Evelyn Cardona, discussed the work of the Brooklyn Coalition Against Family Violence, where she is the director, her own experience as a battered woman, and how she overcame it.
core +1 more source
Nonlocal reflection by photonic barriers
The time behaviour of microwaves undergoing partial reflection by photonic barriers was measured in the time and in the frequency domain. It was observed that unlike the duration of partial reflection by dielectric layers, the measured reflection ...
A. Haibel +16 more
core +2 more sources
Zonal Jets as Transport Barriers in Planetary Atmospheres [PDF]
The connection between transport barriers and potential vorticity (PV) barriers in PV-conserving flows is investigated with a focus on zonal jets in planetary atmospheres. A perturbed PV-staircase model is used to illustrate important concepts. This flow
Beron-Vera, F. J. +5 more
core +2 more sources
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Working to Reduce Poverty: A National Subsidized Employment Proposal
Subsidized employment programs that increase labor supply and demand are a proven, underutilized strategy for reducing poverty in the short and long term.
Indivar Dutta-Gupta +4 more
doaj +1 more source
Storm surge barriers are large movable hydraulic structures which close during a storm surge to prevent coastal floods. In the regions they protect, a failure to close the barrier is often the most likely cause for a catastrophic flood.
Leslie F. Mooyaart +4 more
doaj +1 more source

