Basal Body Protein TbSAF1 Is Required for Microtubule Quartet Anchorage to the Basal Bodies in Trypanosoma brucei. [PDF]
mBio, 2020 Trypanosoma brucei contains a large array of single-copied organelles and structures. Through extensive interorganelle connections, these structures replicate and divide following a strict temporal and spatial order.
Dong X, Lim TK, Lin Q, He CY.
europepmc +6 more sources
Proximity Interactions among Basal Body Components in
mBio, 2017 The basal body shares similar architecture with centrioles in animals and is involved in nucleating flagellar axonemal microtubules in flagellated eukaryotes.
Hung Quang Dang +6 more
doaj +3 more sources
Molecular structure of the intact bacterial flagellar basal body. [PDF]
Nat Microbiol, 2021 The bacterial flagellum is a macromolecular protein complex that enables motility in many species. Bacterial flagella self-assemble a strong, multicomponent drive shaft that couples rotation in the inner membrane to the micrometre-long flagellar filament
Johnson S +8 more
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The human sperm basal body is a complex centrosome important for embryo preimplantation development. [PDF]
Mol Hum Reprod, 2021 The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis has not been directly addressed so far.
Amargant F +6 more
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Intraflagellar transport protein RABL5/IFT22 recruits the BBSome to the basal body through the GTPase ARL6/BBS3. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Bardet-Biedl syndrome (BBS) is a rare human ciliopathy associated with blindness, obesity, and kidney anomalies. It is caused by defects in the assembly or transport of the BBSome, a conserved octamer of BBS proteins, which assists ...
Xue B +7 more
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Electron cryotomography of intact motile cilia defines the basal body to axoneme transition. [PDF]
J Cell Biol, 2020 Greenan et al. use electron cryotomography on intact motile cilia to elucidate how basal bodies template the formation of motile axonemes.
Greenan GA, Vale RD, Agard DA.
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Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. [PDF]
J Cell Biol, 2020 Soh et al. study the organization of Tetrahymena ciliary arrays. Basal body–associated striated fibers organize motile cilia by promoting basal body orientation, reorientation, and resistance to ciliary forces.
Soh AWJ +6 more
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Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission. [PDF]
Life Sci Alliance, 2019 This comprehensive study describes the key role and real-time dynamics of Plasmodium kinesin-8B in microtubule-based basal body and axoneme assembly during flagellum (male gamete) formation and parasite transmission.
Zeeshan M +12 more
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Parental centrioles are dispensable for deuterosome formation and function during basal body amplification. [PDF]
EMBO Rep, 2019 Mammalian epithelial cells use a pair of parental centrioles and numerous deuterosomes as platforms for efficient basal body production during multiciliogenesis. How deuterosomes form and function, however, remain controversial.
Zhao H +6 more
europepmc +2 more sources
CRL4WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2017 The Polo-like kinase homolog in Trypanosoma brucei, TbPLK, plays essential roles in basal body segregation, flagellum attachment and cytokinesis. The level of TbPLK protein is tightly controlled, but the underlying mechanism remains elusive.
Huiqing Hu +3 more
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