Results 21 to 30 of about 1,007,554 (258)

Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

eLife, 2019
Cilia and flagella are conserved eukaryotic organelles essential for cellular signaling and motility. Cilia dysfunctions cause life-threatening ciliopathies, many of which are due to defects in the transition zone (TZ), a complex structure of the ciliary
Jean-André Lapart, Marco Gottardo, Elisabeth Cortier, Jean-Luc Duteyrat, Céline Augière, Alain Mangé, Julie Jerber, Jérôme Solassol, Jay Gopalakrishnan, Joëlle Thomas, Bénédicte Durand   +10 more
doaj   +1 more source

Flattop regulates basal body docking and positioning in mono- and multiciliated cells

eLife, 2014
Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. In this study, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated ...
Moritz Gegg, Anika Böttcher, Ingo Burtscher, Stefan Hasenoeder, Claude Van Campenhout, Michaela Aichler, Axel Walch, Seth G N Grant, Heiko Lickert   +8 more
doaj   +1 more source

The basal bodies of Chlamydomonas reinhardtii [PDF]

, 2016
The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal bodies.
Dutcher, Susan, O\u27Toole, Eileen T
core   +2 more sources

Regulation of cilia abundance in multiciliated cells

eLife, 2019
Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification.
Rashmi Nanjundappa, Dong Kong, Kyuhwan Shim, Tim Stearns, Steven L Brody, Jadranka Loncarek, Moe R Mahjoub   +6 more
doaj   +1 more source

The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly.

PLoS Biology, 2022
In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane.
Pierrick Le Borgne, Logan Greibill, Marine Hélène Laporte, Michel Lemullois, Khaled Bouhouche, Mebarek Temagoult, Olivier Rosnet, Maeva Le Guennec, Laurent Lignières, Guillaume Chevreux, France Koll, Virginie Hamel, Paul Guichard, Anne-Marie Tassin   +13 more
doaj   +1 more source

Repression of GW/P body components and the RNAi microprocessor impacts primary ciliogenesis in human astrocytes

BMC Cell Biology, 2011
Background In most cells, the centriolar component of the centrosome can function as a basal body supporting the formation of a primary cilium, a non-motile sensory organelle that monitors information from the extracellular matrix and relays stimuli into
Rattner Jerome B, Fritzler Marvin J, Moser Joanna J   +2 more
doaj   +1 more source

The management of type 2 diabetes with fixed‐ratio combination insulin degludec/liraglutide (IDegLira) versus basal‐bolus therapy (insulin glargine U100 plus insulin aspart): a short‐term cost‐effectiveness analysis in the UK setting [PDF]

, 2018
Aim: To evaluate the cost‐effectiveness of IDegLira versus basal‐bolus therapy (BBT) with insulin glargine U100 plus up to 4 times daily insulin aspart for the management of type 2 diabetes in the UK.
ADVANCE Collaborative Group, American Diabetes Association Consensus Panel, Anderson, Bagust, Bagust, Billings, Blak, Boye, Chubb, Control Group, Currie, Donnelly, Duckworth, Evans, Forst, Gaede, Gaede, Giugliano, Grandy, Hammer, Holman, Hunt, Hunt, Hunt, Inzucchi, Ismail-Beigi, Johnston, Lee, Matza, McCabe, Meneghini, Mezquita-Raya, National Institute for Health and Care Excellence (NICE), Nauck, Parekh, Peyrot, Peyrot, Ridderstråle, Russell-Jones, Shi, Stettler, The Forum for Injection Technique (FIT), TREND-UK, UK Prospective Diabetes Study (UKPDS) Group, UK Prospective Diabetes Study (UKPDS) Group, Walz, Wang, Wild   +47 more
core   +1 more source

Cellular Mechanisms of Ciliary Length Control

Cells, 2016
Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility ...
Jacob Keeling, Leonidas Tsiokas, Dipak Maskey   +2 more
doaj   +1 more source

Summing the strokes: energy economy in northern elephant seals during large-scale foraging migrations. [PDF]

, 2015
BackgroundThe energy requirements of free-ranging marine mammals are challenging to measure due to cryptic and far-ranging feeding habits, but are important to quantify given the potential impacts of high-level predators on ecosystems.
Adachi, T, Costa, DP, Costa, DP, Crocker, DE, Horning, M, Maresh, JL, Naito, Y, Takahashi, A, Williams, TM   +8 more
core   +1 more source

Structural analysis of S-ring composed of FliFG fusion proteins in marine Vibrio polar flagellar motor

mBio
The marine bacterium Vibrio alginolyticus possesses a polar flagellum driven by a sodium ion flow. The main components of the flagellar motor are the stator and rotor.
Norihiro Takekawa, Tatsuro Nishikino, Jun-ichi Kishikawa, Mika Hirose, Miki Kinoshita, Seiji Kojima, Tohru Minamino, Takayuki Uchihashi, Takayuki Kato, Katsumi Imada, Michio Homma   +10 more
doaj   +1 more source