CRL4WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2017 The Polo-like kinase homolog in Trypanosoma brucei, TbPLK, plays essential roles in basal body segregation, flagellum attachment and cytokinesis. The level of TbPLK protein is tightly controlled, but the underlying mechanism remains elusive.
Huiqing Hu +3 more
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A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis [PDF]
Nature CommunicationsAxoneme assembly constitutes a pivotal process in male gametogenesis of Plasmodium. Plasmodium possesses a unique nuclear envelope-anchored basal body that templates axoneme assembly, distinct from the basal body that templates the axoneme of cilia or ...
Shuzhen Yang +8 more
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Intrinsic clustering of flagellar basal body proteins in E. coli: A self-organization mechanism for assembly and regulation [PDF]
Biochemistry and Biophysics ReportsThe assembly and spatial organization of flagellar basal bodies in Escherichia coli are crucial for motility and chemotaxis. Using fluorescence and single-molecule microscopy, we demonstrate that key basal body proteins, FliF and FlhA, self-organize into
Yun-Sing Sung, De-Fa Hong, Yi-Ren Chang
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Flattop regulates basal body docking and positioning in mono- and multiciliated cells
eLife, 2014 Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. In this study, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated ...
Moritz Gegg +8 more
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Molecular structure of the intact bacterial flagellar basal body. [PDF]
Nat Microbiol, 2021 The bacterial flagellum is a macromolecular protein complex that enables motility in many species. Bacterial flagella self-assemble a strong, multicomponent drive shaft that couples rotation in the inner membrane to the micrometre-long flagellar filament
Johnson S +8 more
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The human sperm basal body is a complex centrosome important for embryo preimplantation development. [PDF]
Mol Hum Reprod, 2021 The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis has not been directly addressed so far.
Amargant F +6 more
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A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. [PDF]
PLoS Pathogens, 2013 The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells.
Julien R C Bergeron +10 more
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Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Bardet–Biedl syndrome (BBS) characteristic of blindness, obesity, and kidney anomalies is a rare human ciliopathy. BBS could result from disrupted ciliary dynamics of the BBSome, a conserved octamer of BBS proteins, which facilitates ...
Sun WY +8 more
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Intraflagellar transport protein RABL5/IFT22 recruits the BBSome to the basal body through the GTPase ARL6/BBS3. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Bardet-Biedl syndrome (BBS) is a rare human ciliopathy associated with blindness, obesity, and kidney anomalies. It is caused by defects in the assembly or transport of the BBSome, a conserved octamer of BBS proteins, which assists ...
Xue B +7 more
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Electron cryotomography of intact motile cilia defines the basal body to axoneme transition. [PDF]
J Cell Biol, 2020 Greenan et al. use electron cryotomography on intact motile cilia to elucidate how basal bodies template the formation of motile axonemes.
Greenan GA, Vale RD, Agard DA.
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