New Tetrahymena basal body protein components identify basal body domain structure [PDF]
The Journal of Cell Biology, 2007 Basal bodies organize the nine doublet microtubules found in cilia. Cilia are required for a variety of cellular functions, including motility and sensing stimuli.
Culver, Brady P. +7 more
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A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. [PDF]
PLoS Pathogens, 2013 The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells.
Julien R C Bergeron +10 more
doaj +2 more sources
A Novel Basal Body Protein That Is a Polo-like Kinase Substrate Is Required for Basal Body Segregation and Flagellum Adhesion in Trypanosoma brucei. [PDF]
J Biol Chem, 2015 Background: The substrates of Polo-like kinase in Trypanosoma brucei are mostly not identified. Results: A basal body protein was identified as a substrate of Polo-like kinase and is required for basal body segregation and flagellum adhesion. Conclusion:
Hu H, Zhou Q, Li Z.
europepmc +2 more sources
Intrinsic clustering of flagellar basal body proteins in E. coli: A self-organization mechanism for assembly and regulation [PDF]
Biochemistry and Biophysics ReportsThe assembly and spatial organization of flagellar basal bodies in Escherichia coli are crucial for motility and chemotaxis. Using fluorescence and single-molecule microscopy, we demonstrate that key basal body proteins, FliF and FlhA, self-organize into
Yun-Sing Sung, De-Fa Hong, Yi-Ren Chang
doaj +1 more source
A specific basal body linker protein provides the connection function for basal body inheritance in trypanosomes. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Centriole/basal body (BB) connections involve two concepts: a tether and a linker. Studies have revealed essential components of the tether, while linker components remain largely unknown. Here, we describe BBLP, a trypanosome protein that is a cytoskeletal component of the linker, localizing between the BB and pro-BB throughout ...
Lai DH +4 more
europepmc +5 more sources
Basal body temperature as a biomarker of healthy aging. [PDF]
Age (Dordr), 2016 Simonsick EM +4 more
europepmc +2 more sources
Journal of Developmental Biology, 2022 The development of multicellular organisms requires a tightly coordinated network of cellular processes and intercellular signalling. For more than 20 years, it has been known that primary cilia are deeply involved in the mediation of intercellular ...
Thorsten Pfirrmann, Christoph Gerhardt
doaj +1 more source
Tetrahymena basal bodies [PDF]
Cilia, 2015 Tetrahymena thermophila is a ciliate with hundreds of cilia primarily used for cellular motility. These cells propel themselves by generating hydrodynamic forces through coordinated ciliary beating. The coordination of cilia is ensured by the polarized organization of basal bodies (BBs), which exhibit remarkable structural and molecular conservation ...
Brian A. Bayless +2 more
openaire +3 more sources
Cilia, 2015 Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus basal bodies and their accessory structures.
Brian J. Mitchell, Siwei Zhang
openaire +2 more sources
Tetrahymena Poc5 is a transient basal body component that is important for basal body maturation. [PDF]
J Cell Sci, 2020 ABSTRACT Basal bodies (BBs) are microtubule-based organelles that act as a template for and stabilize cilia at the cell surface. Centrins ubiquitously associate with BBs and function in BB assembly, maturation and stability. Human POC5 (hPOC5) is a highly conserved centrin-binding protein that binds centrins through Sfi1p-like repeats ...
Heydeck W +7 more
europepmc +4 more sources