Flattop regulates basal body docking and positioning in mono- and multiciliated cells
eLife, 2014 Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. In this study, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated ...
Moritz Gegg +8 more
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CRL4WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2017 The Polo-like kinase homolog in Trypanosoma brucei, TbPLK, plays essential roles in basal body segregation, flagellum attachment and cytokinesis. The level of TbPLK protein is tightly controlled, but the underlying mechanism remains elusive.
Huiqing Hu +3 more
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Basal bodies across eukaryotes series: basal bodies in the freshwater planarian Schmidtea mediterranea [PDF]
Cilia, 2016 The freshwater planarian Schmidtea mediterranea has recently emerged as a valuable model system to study basal bodies (BBs) and cilia. Planarians are free-living flatworms that use cilia beating at the surface of their ventral epidermis for gliding along substrates. The ventral epidermis is composed of multiciliated cells (MCCs) that are similar to the
Azimzadeh, Juliette, Basquin, Cyril
openaire +2 more sources
PLoS Biology, 2022 In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane.
Pierrick Le Borgne +13 more
doaj +1 more source
The management of type 2 diabetes with fixed‐ratio combination insulin degludec/liraglutide (IDegLira) versus basal‐bolus therapy (insulin glargine U100 plus insulin aspart): a short‐term cost‐effectiveness analysis in the UK setting [PDF]
, 2018 Aim: To evaluate the cost‐effectiveness of IDegLira versus basal‐bolus therapy (BBT) with insulin glargine U100 plus up to 4 times daily insulin aspart for the management of type 2 diabetes in the UK.
ADVANCE Collaborative Group +47 more
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Regulation of cilia abundance in multiciliated cells
eLife, 2019 Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification.
Rashmi Nanjundappa +6 more
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BMC Cell Biology, 2011 Background In most cells, the centriolar component of the centrosome can function as a basal body supporting the formation of a primary cilium, a non-motile sensory organelle that monitors information from the extracellular matrix and relays stimuli into
Rattner Jerome B +2 more
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Cellular Mechanisms of Ciliary Length Control
Cells, 2016 Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility ...
Jacob Keeling +2 more
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Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
Cells, 2018 Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole.
Umama Shahid, Priyanka Singh
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Protracted effects of chronic stress on serotonin-dependent thermoregulation [PDF]
, 2015 Chronic stress is known to affect serotonin (5HT) neurotransmission in the brain and to alter body temperature. The body temperature is controlled in part, by the medial preoptic area (mPOA) of the hypothalamus.
Natarajan, Reka +2 more
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