Results 1 to 10 of about 137,170 (147)

Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia

Cells, 2023
Dopamine replacement therapy for Parkinson’s disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity
Osama F. Elabi, Elena Espa, Katrine Skovgård, Silvia Fanni, Maria Angela Cenci   +4 more
doaj   +1 more source

Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism

Neurobiology of Disease, 2021
L-DOPA-induced dyskinesia (LID) is a significant complication of dopamine replacement therapy in Parkinson's disease (PD), and the specific role of different dopamine receptors in this disorder is poorly understood.
Laura Andreoli, Morteza Abbaszadeh, Xiao Cao, Maria Angela Cenci   +3 more
doaj   +1 more source

Motor symptom asymmetry predicts non-motor outcome and quality of life following STN DBS in Parkinson's disease

Scientific Reports, 2022
Risk factors for long-term non-motor symptoms and quality of life following subthalamic nucleus deep brain stimulation (STN DBS) have not yet been fully identified.
Philippe Voruz, Jordan Pierce, Kévin Ahrweiller, Claire Haegelen, Paul Sauleau, Sophie Drapier, Dominique Drapier, Marc Vérin, Julie Péron   +8 more
doaj   +1 more source

Emotions and cognitive control: A comparison of bipolar disorder and schizophrenia

Journal of Affective Disorders Reports, 2021
Background: Bipolar disorder (BP) and schizophrenia (SZ) are both psychiatric conditions characterized by deficits in cognitive control (executive function and attention) and emotion regulation. The emotional Stroop task makes it possible to measure such
Murielle Sollier-Guillery, Alexandra Fortier, Thibaut Dondaine, Jean-Marie Batail, Gabriel Robert, Dominique Drapier, Agnès Lacroix   +6 more
doaj   +1 more source

APOE ε4 allele, along with G206D-PSEN1 mutation, alters mitochondrial networks and their degradation in Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
IntroductionAlzheimer’s disease remains the most common neurodegenerative disorder, depicted mainly by memory loss and the presence in the brain of senile plaques and neurofibrillary tangles.
Irene Costa-Laparra, Elena Juárez-Escoto, Elena Juárez-Escoto, Carlos Vicario, Carlos Vicario, Rosario Moratalla, Rosario Moratalla, Patricia García-Sanz, Patricia García-Sanz   +8 more
doaj   +1 more source

Spatio-temporal dynamics of large-scale electrophysiological networks during cognitive action control in healthy controls and Parkinson's disease patients

NeuroImage, 2022
Among the cognitive symptoms that are associated with Parkinson's disease (PD), alterations in cognitive action control (CAC) are commonly reported in patients. CAC enables the suppression of an automatic action, in favor of a goal-directed one.
Joan Duprez, Judie Tabbal, Mahmoud Hassan, Julien Modolo, Aya Kabbara, Ahmad Mheich, Sophie Drapier, Marc Vérin, Paul Sauleau, Fabrice Wendling, Pascal Benquet, Jean-François Houvenaghel   +11 more
doaj   +1 more source

Biases in facial and vocal emotion recognition in chronic schizophrenia

Frontiers in Psychology, 2014
There has been extensive research on impaired emotion recognition in schizophrenia in the facial and vocal modalities. The literature points to biases toward non-relevant emotions for emotional faces but few studies have examined biases in emotional ...
Thibaut eDondaine, Thibaut eDondaine, Gabriel eRobert, Gabriel eRobert, Julie ePéron, Didier eGrandjean, Marc eVérin, Marc eVérin, Dominique eDrapier, Dominique eDrapier, Bruno eMillet, Bruno eMillet   +11 more
doaj   +1 more source

Rodent models of impulsive–compulsive behaviors in Parkinson's disease: How far have we reached?

Neurobiology of Disease, 2015
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive–compulsive behaviors (ICBs).
M. Angela Cenci, Veronica Francardo, Sean S. O'Sullivan, Hanna S. Lindgren   +3 more
doaj   +1 more source

Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease

Neurobiology of Disease, 2017
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow ...
Irene Sebastianutto, Maria Angela Cenci, Tim Fieblinger   +2 more
doaj   +1 more source

Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion

Neurobiology of Disease, 2016
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD).
Francesco Bez, Veronica Francardo, M. Angela Cenci   +2 more
doaj   +1 more source