Results 1 to 10 of about 241,417 (185)

Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia

open access: yesCells, 2023
Dopamine replacement therapy for Parkinson’s disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity
Osama F. Elabi   +4 more
doaj   +1 more source

Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism

open access: yesNeurobiology of Disease, 2021
L-DOPA-induced dyskinesia (LID) is a significant complication of dopamine replacement therapy in Parkinson's disease (PD), and the specific role of different dopamine receptors in this disorder is poorly understood.
Laura Andreoli   +3 more
doaj   +1 more source

Motor symptom asymmetry predicts non-motor outcome and quality of life following STN DBS in Parkinson's disease

open access: yesScientific Reports, 2022
Risk factors for long-term non-motor symptoms and quality of life following subthalamic nucleus deep brain stimulation (STN DBS) have not yet been fully identified.
Philippe Voruz   +8 more
doaj   +1 more source

Emotions and cognitive control: A comparison of bipolar disorder and schizophrenia

open access: yesJournal of Affective Disorders Reports, 2021
Background: Bipolar disorder (BP) and schizophrenia (SZ) are both psychiatric conditions characterized by deficits in cognitive control (executive function and attention) and emotion regulation. The emotional Stroop task makes it possible to measure such
Murielle Sollier-Guillery   +6 more
doaj   +1 more source

APOE ε4 allele, along with G206D-PSEN1 mutation, alters mitochondrial networks and their degradation in Alzheimer’s disease

open access: yesFrontiers in Aging Neuroscience, 2023
IntroductionAlzheimer’s disease remains the most common neurodegenerative disorder, depicted mainly by memory loss and the presence in the brain of senile plaques and neurofibrillary tangles.
Irene Costa-Laparra   +8 more
doaj   +1 more source

Spatio-temporal dynamics of large-scale electrophysiological networks during cognitive action control in healthy controls and Parkinson's disease patients

open access: yesNeuroImage, 2022
Among the cognitive symptoms that are associated with Parkinson's disease (PD), alterations in cognitive action control (CAC) are commonly reported in patients. CAC enables the suppression of an automatic action, in favor of a goal-directed one.
Joan Duprez   +11 more
doaj   +1 more source

Biases in facial and vocal emotion recognition in chronic schizophrenia

open access: yesFrontiers in Psychology, 2014
There has been extensive research on impaired emotion recognition in schizophrenia in the facial and vocal modalities. The literature points to biases toward non-relevant emotions for emotional faces but few studies have examined biases in emotional ...
Thibaut eDondaine   +11 more
doaj   +1 more source

Time representation in reinforcement learning models of the basal ganglia [PDF]

open access: yes, 2013
Reinforcement learning (RL) models have been influential in understanding many aspects of basal ganglia function, from reward prediction to action selection.
Alvaro F. Nieto Guil   +7 more
core   +5 more sources

Rodent models of impulsive–compulsive behaviors in Parkinson's disease: How far have we reached?

open access: yesNeurobiology of Disease, 2015
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive–compulsive behaviors (ICBs).
M. Angela Cenci   +3 more
doaj   +1 more source

Basal ganglia role in learning rewarded actions and executing previously learned choices: Healthy and diseased states [PDF]

open access: yes, 2020
The basal ganglia (BG) is a collection of nuclei located deep beneath the cerebral cortex that is involved in learning and selection of rewarded actions. Here, we analyzed BG mechanisms that enable these functions.
Atwood, Brady   +2 more
core   +1 more source

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