Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]
, 2017 Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca +7 more
core +1 more source
Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Prevalence and temporal dynamics of transient oscillations in the beta frequency band (15 to 35 Hz), referred to as β bursts, are correlated with motor performance.
H. Cagnan +11 more
semanticscholar +1 more source
Receptors in the Basal Ganglia [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1987 ABSTRACT:The study of neurotransmitter receptors aids in the understanding of the normal anatomy, pharmacology, therapeutics and pathophysiology of disease processes involving the basal ganglia. Receptors may be studied in vitro by homogenate binding experiments, enzyme analysis or quantitative autoradiography and in vivo with positron emission ...
openaire +3 more sources
Remembering Forward: Neural Correlates of Memory and Prediction in Human Motor Adaptation [PDF]
, 2012 We used functional MR imaging (FMRI), a robotic manipulandum and systems identification techniques to examine neural correlates of predictive compensation for spring-like loads during goal-directed wrist movements in neurologically-intact humans ...
Houk, James +6 more
core +2 more sources
Emotions and cognitive control: A comparison of bipolar disorder and schizophrenia
Journal of Affective Disorders Reports, 2021 Background: Bipolar disorder (BP) and schizophrenia (SZ) are both psychiatric conditions characterized by deficits in cognitive control (executive function and attention) and emotion regulation. The emotional Stroop task makes it possible to measure such
Murielle Sollier-Guillery +6 more
doaj
PDZD8 is not the ‘functional ortholog’ of Mmm1, it is a paralog [version 1; referees: 2 approved]
F1000Research, 2018 Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells.
Jeremy G. Wideman +3 more
doaj +1 more source
Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]
, 2020 Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S. +8 more
core +1 more source
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders
Psychiatry and Clinical Neurosciences, 2019 Over the last few decades, advances in human and animal‐based techniques have greatly enhanced our understanding of the neural mechanisms underlying psychiatric disorders.
Tom Macpherson, T. Hikida
semanticscholar +1 more source
Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]
, 2008 The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G. +3 more
core +4 more sources
The Anatomy of the Basal Ganglia [PDF]
, 2016 The basal ganglia are a set of subcortical nuclei that receive inputs from the entire cortex and send outputs via the thalamus to different frontal cortical areas. Several parallel and segregated closed cortico-striatal-thalamo-cortical loops serve a role in selecting desirable actions and suppressing undesirable ones.
Watkins, Kate E., Jenkinson, Ned
openaire +3 more sources