Results 31 to 40 of about 28,372,502 (356)

Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia

Neurobiology of Disease, 2004
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi, Jenny E. Westin, Manolo Carta, Molly E. Eaton, Katarzyna Kuter, Andrzej Dekundy, Martin Lundblad, M. Angela Cenci   +7 more
doaj   +1 more source

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

Neurobiology of Disease, 2011
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo, Alessandra Recchia, Nataljia Popovic, Daniel Andersson, Hans Nissbrandt, M. Angela Cenci   +5 more
doaj   +1 more source

Cerebellum: an explanation for dystonia? [PDF]

, 2017
Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas.
Berardelli, Alfredo, Bologna, Matteo
core   +1 more source

Does the motor system need intermittent control? [PDF]

, 2014
Explanation of motor control is dominated by continuous neurophysiological pathways (e.g. trans-cortical, spinal) and the continuous control paradigm.
Brembs, Cisek, Cohen, Cornelis van de Kamp, Diedrichsen, Dux, Frank, Gawthrop, Gawthrop, Gawthrop, Gawthrop, Gollee, Haber, Hardwick, Henrik Gollee, Houk, Ian David Loram, Kleinman, Lakie, Levison, Loram, Loram, Loram, Loram, Loram, Loram, Marsden, Martin Lakie, Peter J. Gawthrop, Pruszynski, Redgrave, Redgrave, Ronco, Todorov, Van De Kamp, Van de Kamp, Vince, Yin   +37 more
core   +2 more sources

Disrupted basal ganglia—thalamocortical loops in focal to bilateral tonic-clonic seizures

bioRxiv, 2019
Focal to bilateral tonic-clonic seizures are associated with lower quality of life, higher risk of seizure-related injuries, increased chance of sudden unexpected death, as well as unfavorable treatment outcomes.
Xiaosong He, G. Chaitanya, Burcu Asma, L. Caciagli, D. Bassett, J. Tracy, M. Sperling   +6 more
semanticscholar   +1 more source

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

Neurobiology of Disease, 2009
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane, Patrik Brundin, M. Angela Cenci   +2 more
doaj   +1 more source

Childhood Adversity is Associated with Left Basal Ganglia Dysfunction During Reward Anticipation in Adulthood [PDF]

, 2009
Background: Childhood adversity increases the risk of psychopathology, but the neurobiological mechanisms underlying this vulnerability are not well-understood.
Anda, Anisman, Avram J. Holmes, Beck, Bjork, Blumenthal, Bremner, Cabib, Carlson, Chapman, Charney, Daniel G. Dillon, Deichmann, Diego A. Pizzagalli, Dillon, Dong, Drevets, Dube, Dube, Epstein, Fawcett, First, Fischl, Frank, Gabbay, George, Gladstone, Guyer, Harkness, Heim, Jeffrey L. Birk, Kalinichev, Karlen Lyons-Ruth, Kaufman, Knutson, Lumley, Lyons-Ruth, Lyons-Ruth, Martin, Matthews, Meyer, Miller, Nancy Brooks, Navalta, Nelson, Norris, Pizzagalli, Pollak, Pryce, Radloff, Samanez-Larkin, Schott, Smith, Starkstein, Strauss, Tae, Teicher, Tomer, Vataja, Volkow, Watson, Widom, Willner   +62 more
core   +1 more source

Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features

Neurological Sciences, 2019
Basal ganglia calcifications could be incidental findings up to 20% of asymptomatic patients undergoing CT or MRI scan. The presence of neuropsychiatric symptoms associated with bilateral basal ganglia calcifications (which could occur in other peculiar ...
G. Donzuso, G. Mostile, A. Nicoletti, M. Zappia   +3 more
semanticscholar   +1 more source

Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]

, 2012
Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor ...
Park, Choongseok, Rubchinsky, Leonid
core   +6 more sources

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

Neurobiology of Disease, 2008
The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD).
E.L. Lane, D. Soulet, L. Vercammen, M.A. Cenci, P. Brundin   +4 more
doaj   +1 more source