Results 51 to 60 of about 27,335,908 (329)

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment

npj Parkinson's Disease
Dopamine replacement therapy for Parkinson’s disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining ...
Mirjam Wolfschlag, Elena Espa, Katrine Skovgård, Pär Halje, Maria Angela Cenci   +4 more
doaj   +1 more source

The causal interaction in human basal ganglia

Scientific Reports, 2021
The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified.
Clara Rodriguez-Sabate, Albano Gonzalez, Juan Carlos Perez-Darias, Ingrid Morales, Manuel Rodriguez   +4 more
doaj   +1 more source

Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]

, 2016
There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M., McGuinness, Dagmara, Payne, Anthony P., Shields, Paul G.   +3 more
core   +2 more sources

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Spatio-temporal dynamics of large-scale electrophysiological networks during cognitive action control in healthy controls and Parkinson's disease patients

NeuroImage, 2022
Among the cognitive symptoms that are associated with Parkinson's disease (PD), alterations in cognitive action control (CAC) are commonly reported in patients. CAC enables the suppression of an automatic action, in favor of a goal-directed one.
Joan Duprez, Judie Tabbal, Mahmoud Hassan, Julien Modolo, Aya Kabbara, Ahmad Mheich, Sophie Drapier, Marc Vérin, Paul Sauleau, Fabrice Wendling, Pascal Benquet, Jean-François Houvenaghel   +11 more
doaj  

Exploring the cognitive and motor functions of the basal ganglia: An integrative review of computational cognitive neuroscience models

Frontiers in Computational Neuroscience, 2013
Many computational models of the basal ganglia have been proposed over the past twenty-five years. While computational neuroscience models have focused on closely matching the neurobiology of the basal ganglia, computational cognitive neuroscience models
Sebastien eHelie, Srinivasa eChakravarthy, Ahmed A. Moustafa   +2 more
doaj   +1 more source

A basal ganglia inspired model of action selection evaluated in a robotic survival task. [PDF]

, 2003
The basal ganglia system has been proposed as a possible neural substrate for action selection in the vertebrate brain. We describe a robotic implementation of a model of the basal ganglia and demonstrate the capacity of this system to generate adaptive ...
Cuzin, V., Girard, B., Guillot, A., Gurney, K.N., Prescott, T.J.   +4 more
core   +3 more sources

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source

Neuropeptide Co-Release with Gaba May Explain Functional Non-Monotonic Uncertainty Responses in Dopamine Neurons [PDF]

, 2007
Co-release of the inhibitory neurotransmitter GABA and the neuropeptide substance-P (SP) from single axons is a conspicuous feature of the basal ganglia, yet its computational role, if any, has not been resolved.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source