Integration of navigation and action selection functionalities in a computational model of cortico-basal ganglia-thalamo-cortical loops [PDF]
, 2005 This article describes a biomimetic control architecture affording an animat both action selection and navigation functionalities. It satisfies the survival constraint of an artificial metabolism and supports several complementary navigation strategies ...
Berthoz, Alain +4 more
core +4 more sources
A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
, 2017 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla +2 more
core +1 more source
Ожирение и метаболизм, 2020 Background: Hypothalamic obesity often develops after surgical treatment of craniopharyngioma and is characterized by rapid weight gain, high frequency of metabolic disorders, body composition specificity and resistance to standard lifestyle modification
Pavel L. Okorokov +6 more
doaj +1 more source
Citrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis
Communications Biology, 2022 Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca2+ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this
Zhanat Koshenov +6 more
doaj +1 more source
Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]
, 2020 High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ +9 more
core +2 more sources
Adaptive Capacity and Features of Energy Metabolism in Patients with Diabetes Mellitus Type 2
Mìžnarodnij Endokrinologìčnij Žurnal, 2013 The study of the processes of adaptation and characteristics of energy metabolism in patients with diabetes mellitus (DM) type 2 can serve as a basis for determining their role in the pathogenesis of this disease and contribute to the development of new ...
P.P. Chernysh +5 more
doaj +1 more source
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
core +1 more source
Journal of Pediatrics Review, 2022 Background: Overweight and obesity are prominent threats to pediatric health. The prevalence of childhood obesity has dramatically been increasing worldwide.
Vahid Saleh, Roghayyeh Afroundeh
doaj
Serum metabolome and gut microbiome alterations in broiler chickens supplemented with lauric acid
Poultry Science, 2021 : Antibiotic overuse in poultry husbandry poses a potential threat to meat safety and human health. Lauric acid (LA) is a primary medium-chain fatty acid (MCFA) with a strong antibacterial capacity.
Yanping Wu +7 more
doaj +1 more source
Modelling aspects of oviduct fluid formation in vitro [PDF]
, 2016 © 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation.
Arnold, Georg +11 more
core +2 more sources