Results 91 to 100 of about 9,108 (216)

A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis [PDF]

, 2010
The signs and symptoms of ankylosing spondylitis (AS) respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients.
Ciccia, F., Ferrante, A., Giardina, A., Impastato, R., Miceli, M., Principato, A., Triolo, G.   +6 more
core   +1 more source

Core Set of Responsive and Discriminatory Measures for Use in Pragmatic Trials of Youth With Axial Juvenile Spondyloarthritis

Arthritis Care &Research, Volume 77, Issue 10, Page 1229-1239, October 2025.
Objective The objective of this study was to determine a core set of measures for youth with juvenile spondyloarthritis and axial disease (axJSpA), using the juvenile arthritis working group Outcome Measures in Rheumatology framework. Methods This was a prospective multicenter study of youth with axJSpA.
Timothy G. Brandon, Rui Xiao, Daniel J. Lovell, Edward Oberle, Matthew L. Stoll, Nancy A. Chauvin, Michael L. Francavilla, Walter P. Maksymowych, Pamela F. Weiss   +8 more
wiley   +1 more source

Avaliação da aterosclerose subclínica e de níveis plasmáticos de LDL minimamente modificada em pacientes com espondilite anquilosante e sua correlação com a atividade da doença [PDF]

, 1931
IntroductionAccelerated atherosclerosis has been shown in some autoimmune diseases, mainly in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Although high preva- lence of corticosteroids use may be a confounding factor due to their detrimental ...
Fernanda Teles Ceccon, Valderílio Feijó Azevedo, Carlos A. Engelhorn, Dulcinéia S.P. Abdalla, Tanize E.S. Faulin, Luis Cesar Guarita-Souza, Roberto Pecoits-Filho, José Rocha Faria-Neto, Berliner, Ross, Virella, Tsimikas, Witztum, Cazzolato, Paramo, Manzi, Dhawan, Troelsen, Sattar, Turesson, Kim, Azevedo, Divecha, Van Der Linden, Demuth, Avogaro, Lorenz, Milovanovic, Avouac, Sari, Mano, Manzi, Del Rincon, Mathieu, Frostegard, Cushing, Shih, Damasceno, Hahn, Peters, Bruce, Davis   +41 more
core   +2 more sources

JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome usually involves bones, joints, and skin. Due to a lack of known pathogenesis and clinical trials, there is no standard treatment of SAPHO syndrome. Because none of the current treatments have a high efficacy and the risk of relapse is high, new treatment options for ...
Patrick Fazeli, Saeed Bahramian, Kimia Farahmand, Hamed Ghoshouni, Yalda Farahmand, Amirali Soheili, Leyla Bagheri, Huria Memari, Aydin Feyzi, Seyed Mohammad Vahabi   +9 more
wiley   +1 more source

Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial [PDF]

, 2014
Objective: Assess ustekinumab efficacy (week 24/week 52) and safety (week 16/week 24/week 60) in patients with active psoriatic arthritis (PsA) despite treatment with conventional and/or biological anti-tumour necrosis factor (TNF) agents. Methods: In
Alten, R., Birbara, C., Boh, E., Braun, J., Budd, J., Chattapadhyay, C., Chudzik, D., Claudepierre, P., Cooper, R., Dooley, L. T., Doyle, M. K., Drescher, E., Dutz, J., Edwards, C., El-Kadi, H., Elewski, B., Erlacher, L., Flipo, R., Fretzin, S., George, E., Gladstein, G., Gottlieb, A. B., Griffin, R., Grisanti, M., Guenther, L., Gulliver, W., Hobbs, K., Huang, E., Ilivanova, E., Jeka, S., Kavanaugh, A., Khraishi, M., Kokhan, M., Korman, N., Kunynetz, R., Leonardi, C., Lessard, C., Li, S., Lindquist, U., Martin, A., Matheson, R., McInnes, I.B., Mendelsohn, A. M., Murphy, F., Nasonov, E., Palmer, W., Papp, K., Perate, M., Puig, L., Rahman, P., Rech, J., Rell-Bakalarska, M., Rich, P., Ritchlin, C., Rosen, C., Rudin, A., Ruppert-Roth, A., Scheinecker, C., Seigel, S., Shaikh, S., Sheeran, T., Shen, Y.-K., Shergy, W., Siegel, E., Sierakowski, S., Sofen, H., Szanto, S., Tahir, H., Telegdy, E., Toth, D., Walker, D., Wang, Y., Whitman, M., Wilson, A., Witt, M., Wollenhaupt, J., Zoschke, D., Zubrzycka, A.   +77 more
core   +1 more source

Serum Levels of 54 Cytokines and Chemokines Reveal Distinct Inflammatory Signatures in Ankylosing Spondylitis

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
ABSTRACT Background Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disorder predominantly involving the axial skeleton. Understanding the cytokine and chemokine signatures in AS is crucial for elucidating disease mechanisms and identifying potential diagnostic biomarkers.
Huan Li, Ting Wang, Mingze Li, Wei Su, Ying Lv, Jialing Xiao, Xiaoxin Guo, Kai Dong, Chengzi Gan, Jing Zhu, Bo Gong   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Adalimumab, Secukinumab, and Upadacitinib in Psoriatic Arthritis: A Prospective Cohort Study Based on PARWCH Cohort

The Journal of Dermatology, Volume 52, Issue 10, Page 1527-1535, October 2025.
ABSTRACT Psoriatic arthritis (PsA) is a chronic inflammatory disease, with prevalence among psoriasis patients ranging from 6% to 42% across populations. Although targeted therapies such as adalimumab (ADA), secukinumab (SEC), and upadacitinib (UPA) have demonstrated efficacy in randomized controlled trials, real‐world head‐to‐head comparisons remain ...
Yiyi Wang, Jingya Gao, Furong Li, Luyuan Li, Yue Xiao, Hongxiang Hu, Xiya Peng, Min Yang, Dan Hao, Wei Yan, Dengmei Xia, Wei Li   +11 more
wiley   +1 more source

Interchangeability of patient pain, fatigue and global scores in patients with spondyloarthritis - a registry-based simulation study

BMC Rheumatology
Background To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose ...
Stylianos Georgiadis, Daniela Di Giuseppe, Almut Scherer, Merete Lund Hetland, Gareth T. Jones, Bente Glintborg, Anne Gitte Loft, Johan K. Wallman, Brigitte Michelsen, Eirik Klami Kristianslund, Ayten Yazici, Merih Birlik, Jakub Závada, Michael J. Nissen, Adrian Ciurea, Bjorn Gudbjornsson, Olafur Palsson, Ziga Rotar, Matija Tomšič, Heikki Relas, Johanna Huhtakangas, Ana Maria Rodrigues, Maria José Santos, Isabel Castrejon, Federico Díaz-González, Marleen van de Sande, Pasoon Hellamand, Lykke Midtbøll Ørnbjerg   +27 more
doaj   +1 more source

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis [PDF]

, 2016
The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the severity of their clinical parameters.
Blanco García, Francisco Javier, Brüges Armas, Jácome, Coto García, Eliecer, Coto Segura, Pablo, Díaz Bulnes, P., Díaz Peña, Roberto, López Larrea, Carlos, López Vázquez, Antonio, Martínez Camblor, Pablo, Mulero, J., Pinto, José Antonio, Queiro Silva, Rubén, Sánchez, Alejandra, Vidal Castiñeira, José Ramón   +13 more
core   +6 more sources

Diverse Treatment Goals in Psoriatic Arthritis: Insights From Participants in the PARC Cohort

Arthritis Care &Research, Volume 77, Issue 8, Page 1007-1013, August 2025.
Objective The aim of this study was to examine patient‐reported treatment goals among individuals with psoriatic arthritis. Methods Participants in the Psoriatic Arthritis Research Consortium completed standardized assessments, including patient‐reported outcome (PROs) instruments, between 2017 and 2020.
Astia Allenzara, Kathleen Bush, M. Elaine Husni, Soumya M. Reddy, Jose U. Scher, Ethan Craig, Joelle Koplin, Jessica A. Walsh, Alexis Ogdie   +8 more
wiley   +1 more source