Results 31 to 40 of about 9,108 (216)

Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W). [PDF]

, 2020
OBJECTIVES: To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive ...
Baraliakos, X., Bertram, C.C., Bosch, F. van den, Carlier, H., COAST-V Study Grp, COAST-W Study Grp, Deodhar, A., Dougados, M., Ermann, J., Gallo, G., Gensler, L.S., Heijde, D. van der, Landewe, R., Li, X.Q., Maksymowych, W.P., Sieper, J., Tomita, T., Walsh, J.A., Wei, J.C.C., Zhao, F.Y.   +19 more
core   +3 more sources

Persistent clinical efficacy and safety of anti-tumour necrosis factor \textgreeka therapy with infliximab in patients with ankylosing spondylitis over 5 years: evidence for different types of response [PDF]

, 2008
Background: There is insufficient evidence for the long-term efficacy and safety of anti-tumour necrosis factor therapy in patients with ankylosing spondylitis (AS).
Alten, R., Baraliakos, X., Braun, J., Burmester, G., Fritz, C., Krause, A., Listing, J., Schewe, Stefan, Schneider, M., Sieper, J., Sörensen, H., Zeidler, H.   +11 more
core   +1 more source

SAT0260 Eligibility criteria for tnfi therapy in axspa: going beyond basdai [PDF]

Annals of the Rheumatic Diseases, 2018
Background A BASDAI ≥4 has been often required to start TNFi therapy in patients with axSpA. However, this cut-off of high disease activity (HDA) is largely arbitrary. Unlike BASDAI, ASDAS incorporates objective measures (e.g. CRP) and has a validated definition of HDA (≥2.1). It has thus been suggested that ASDAS could also be used to guide treatment
J.A. Marona, A. Sepriano, S. Rodrigues-Manica, F. Pimentel-Santos, A.F. Mourão, N. Gouveia, J.C. Branco, F. Vinagre, R. Roque, J. Rovisco, M.L. Marques, J. Tavares-Costa, J. Silva, H. Santos, N. Madeira, E. Vieira-Sousa, R. Machado, M. Bernardes, R. Ferreira, S. Ramiro   +19 more
openaire   +1 more source

Low BASDAI score alone is not a good predictor of anti-tumor necrosis factor treatment efficacy in ankylosing spondylitis: a retrospective cohort study

BMC Musculoskeletal Disorders, 2021
Background The purpose of this study was to determine the prevalence of high disease activity as measured using the Ankylosing Spondylitis Disease Activity Score (ASDAS) in ankylosing spondylitis (AS) patients who nonetheless have low Bath Ankylosing ...
Bora Nam, Bon San Koo, Tae-Han Lee, Ji-Hui Shin, Jin-Ju Kim, Seunghun Lee, Kyung Bin Joo, Tae-Hwan Kim   +7 more
doaj   +1 more source

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Ritchlin, CT, Kavanaugh, A, Gladman, DD, Mease, PJ, Helliwell, P, Boehncke, W-H, de Vlam, K, Fiorentino, D, FitzGerald, O, Gottlieb, AB, McHugh, NJ, Nash, P, Qureshi, AA, Soriano, ER, Taylor, WJ, GRAPPA   +15 more
core   +1 more source

Evaluation of the Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index in Ankylosing Spondylitis Patients

İstanbul Medical Journal, 2023
Introduction: The aim of this study was to investigate the relationship between the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with ankylosing spondylitis (AS).
Burak Tayyip Dede, Berat Bulut, Muhammed Oğuz, Fatih Bağcıer, Ebru Aytekin   +4 more
doaj   +1 more source

GUIDELINES FOR THE ASSESSMENT OF DISEASE ACTIVITY AND FUNCTIONAL STATUS IN PATIENTS WITH ANKYLOSING SPONDYLITIS IN CLINICAL PRACTICE

Научно-практическая ревматология, 2017
The paper gives the recommendations for the assessment of disease activity and functional status in patients with ankylosing spondylitis in clinical practice, which have been developed by experts, by taking into account international and Russian ...
T. V. Dubinina, I. Z. Gaidukova, A. A. Godzenko, S. A. Lapshina, A. P. Rebrov, O. A. Rumyantseva, V. V. Badokin, A. G. Bochkova, O. V. Bugrova, A. I. Dubikov, O. N. Ivanova, T. V. Korotaeva, O. B. Nesmeyanova, I. P. Nikishina, E. N. Otteva, T. A. Raskina, A. V. Smirnov, A. V. Sitalo, Sh. F. Erdes   +18 more
doaj   +1 more source

Sustained low functional impairment in axial spondyloarthritis (axSpA): which are the primary outcomes that should be targeted to achieve this?

Arthritis Research & Therapy, 2023
Objectives To (i) determine whether sustained disease activity states, as measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS), impact function, and (ii) evaluate ...
Walter P. Maksymowych, Robert D. Inman, Louis Bessette, Proton Rahman, Emmanouil Rampakakis, Odalis Asin-Milan, Meagan Rachich, Anne Marilise Marrache, Allen J. Lehman   +8 more
doaj   +1 more source

Physical activity and sedentary behaviour and their associations with clinical measures in axial spondyloarthritis [PDF]

, 2019
Engaging in physical activity (PA) is a key aspect in the management of axial spondyloarthritis (axial SpA), however, its relationship with clinical measures is unknown.
Cameron, Sara, Coulter, Elaine, McDonald, Marie Therese, Paul, Lorna, Siebert, Stefan   +4 more
core   +3 more sources

The effect of ixekizumab on axial manifestations in patients with psoriatic arthritis from two phase III clinical trials: SPIRIT-P1 and SPIRIT-P2

Therapeutic Advances in Musculoskeletal Disease, 2023
Background: Psoriatic arthritis (PsA) is a chronic inflammatory condition predominantly affecting the peripheral joints. However, some patients with PsA can experience axial involvement which is manifested with back pain and associated with increased ...
Atul Deodhar, Dafna Gladman, Rebecca Bolce, David Sandoval, So Young Park, Soyi Liu Leage, Peter Nash, Denis Poddubnyy   +7 more
doaj   +1 more source