Results 81 to 90 of about 486,575 (254)

Genome-wide nucleotide patterns and potential mechanisms of genome divergence following domestication in maize and soybean

open access: yesGenome Biology, 2019
Background Plant domestication provides a unique model to study genome evolution. Many studies have been conducted to examine genes, genetic diversity, genome structure, and epigenome changes associated with domestication.
Jinyu Wang   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Nest climate and blood quality of two host species of the ectoparasitic Philornis downsi in the Galapagos Islands as factors of larval development

open access: yesFrontiers in Ecology and Evolution
The avian vampire fly is an invasive species on the Galapagos Islands, where its hematophagous larvae utilize nestling birds as hosts. It poses a serious threat to populations and species of Darwin finches and other avian species.
Courtney L. Pike   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Event Representations With Tensor-Based Compositions

open access: yesProceedings of the AAAI Conference on Artificial Intelligence, 2018
Robust and flexible event representations are important to many core areas in language understanding. Scripts were proposed early on as a way of representing sequences of events for such understanding, and has recently attracted renewed attention.
Noah Weber   +2 more
openaire   +2 more sources

The development of cream-mask base composition for androgenetic alopecia prevention and treatment

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
Aim. Androgenetic Alopecia (AA) treatment nowadays is still a difficult task of dermatology as the range of drugs that affect the pathological link of disease and are safe for prolonged use, is limited. Methods and results. The purpose of the work was
M. I. Fedorovska
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The study of structural-mechanical characteristics of the ointment with aminexil

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018
The estimation of rheological characteristics is an important and essential fragment of investigations for creating semisolid dosage forms for dermatologic practice.
Zhamaly Karym   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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