Results 101 to 110 of about 967,825 (378)

Mitochondrial DNA, base excision repair and neurodegeneration [PDF]

DNA Repair, 2008
Neurodegeneration is a growing public health concern because of the rapid increase in median and maximum life expectancy in the developed world. Mitochondrial dysfunction seems to play a critical role in neurodegeneration, likely owing to the high energy demand of the central nervous system and its sole reliance on oxidative metabolism for energy ...
de Souza-Pinto, Nadja C., Wilson III,, David M., Stevnsner, Tinna V., Bohr, Vilhelm   +3 more
openaire   +4 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Capacity of Wireless Distributed Storage Systems with Broadcast Repair [PDF]

arXiv, 2017
In wireless distributed storage systems, storage nodes are connected by wireless channels, which are broadcast in nature. This paper exploits this unique feature to design an efficient repair mechanism, called broadcast repair, for wireless distributed storage systems in the presence of multiple-node failures.
arxiv  

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Journal of Clinical Investigation, 2016
Alterations in the apoptosis of immune cells have been associated with autoimmunity. Here, we have identified a homozygous missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 (NEIL3) that abolished ...
M. Massaad, Jia Zhou, D. Tsuchimoto, J. Chou, H. Jabara, E. Janssen, Salomé Glauzy, Brennan Olson, H. Morbach, Toshiro K. Ohsumi, K. Schmitz, Markianos Kyriacos, J. Kane, K. Torisu, Y. Nakabeppu, L. Notarangelo, E. Chouery, A. Mégarbané, P. Kang, Eman Al-Idrissi, Hasan Aldhekri, E. Meffre, M. Mizui, G. Tsokos, J. Manis, W. Al-Herz, S. Wallace, R. Geha   +27 more
semanticscholar   +1 more source

Excision repair of DNA base damage

Life Sciences, 1974
Abstract Exposure of cells to exogenous physical and chemical agents can result in damage to the DNA bases. DNA damage can lead to mutation, malignant transformation and cell death and may possibly be involved in cellular aging. Structurally related base modifications are expected to have similar biological effects regardless of the agent responsible
Department of Biochemistry, J. Hillis Miller Health Center, Box 724 MSB, University of Florida, Gainesville, Florida 32610, USA ( host institution ), Cerutti, Peter A. ( author )   +1 more
openaire   +4 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Optimal Locally Repairable Systematic Codes Based on Packings [PDF]

arXiv, 2016
Locally repairable codes are desirable for distributed storage systems to improve the repair efficiency. In this paper, we first build a bridge between locally repairable code and packing. As an application of this bridge, some optimal locally repairable codes can be obtained by packings, which gives optimal locally repairable codes with flexible ...
arxiv  

Breakage of cytoplasmic chromosomes by pathological DNA base excision repair

Nature, 2022
Shangming Tang, Ema Stokasimov, Yuxiang Cui, D. Pellman   +3 more
semanticscholar   +1 more source

A Rule-Based Model of Base Excision Repair [PDF]

, 2014
There are ongoing debates in the DNA repair community on whether the coordination of DNA repair is achieved by means of direct protein-protein interactions or whether substrate specificity is sufficient to explain how DNA intermediates are channeled from one repair enzyme to the other. In order to address these questions we designed a model of the Base
Köhler, Agnes, Krivine, Jean, Vidmar, Jakob   +2 more
openaire   +3 more sources