Results 121 to 130 of about 967,825 (378)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Surjectivity of the etale excision map for homotopy invariant framed presheaves [PDF]
arXiv, 2018 The category of framed correspondences Fr_*(k), framed presheaves and framed sheaves were invented by Voevodsky in his unpublished notes [17]. Based on the notes [17] a new approach to the classical Morel--Voevodsky motivic stable homotopy theory was developed by G.Garkusha and I.Panin in [8]. The purpose of this paper is to prove Theorem 1.1 stating
arxiv
FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC
PLoS Genetics, 2016 FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair.
John Lalith Charles Richard +11 more
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
A Family of Erasure Correcting Codes with Low Repair Bandwidth and Low Repair Complexity [PDF]
arXiv, 2015 We present the construction of a new family of erasure correcting codes for distributed storage that yield low repair bandwidth and low repair complexity. The construction is based on two classes of parity symbols. The primary goal of the first class of symbols is to provide good erasure correcting capability, while the second class facilitates node ...
arxiv
Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA.
Chemical Reviews, 2016 Base excision repair (BER) is one of several DNA repair pathways found in all three domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs continuously to the nitrogenous bases in DNA, and its critical role in maintaining
A. Drohat, Christopher T. Coey
semanticscholar +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer
Journal of Cancer, 2016 Gut microbiota are required for host nutrition, energy balance, and regulating immune homeostasis, however, in some cases, this mutually beneficial relationship becomes twisted (dysbiosis), and the gut flora can incite pathological disorders including ...
Debolina Ray, D. Kidane
semanticscholar +1 more source
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
MintHint: Automated Synthesis of Repair Hints [PDF]
arXiv, 2013 Being able to automatically repair programs is an extremely challenging task. In this paper, we present MintHint, a novel technique for program repair that is a departure from most of today's approaches. Instead of trying to fully automate program repair, which is often an unachievable goal, MintHint performs statistical correlation analysis to ...
arxiv