Results 121 to 130 of about 59,740 (306)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

DNA scanning by base excision repair enzymes and implications for pathway coordination

, 2018
Michael J. Howard, Samuel H. Wilson
openalex   +2 more sources

Vertebrate POLQ and POLβ Cooperate in Base Excision Repair of Oxidative DNA Damage [PDF]

, 2006
Michio Yoshimura, Masaoki Kohzaki, Jun Nakamura, Kenjiro Asagoshi, Eiichiro Sonoda, Esther W. Hou, Rajendra Prasad, Samuel H. Wilson, Keizo Tano, Akira Yasui, Li Lan, Mineaki Seki, Richard D. Wood, Hiroshi Arakawa, Jean-Marie Buerstedde, Helfrid Hochegger, Takashi Okada, Masahiro Hiraoka, Shunichi Takeda   +18 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System [PDF]

, 2020
Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski   +3 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair

Medicina
DNA is continuously exposed to endogenous and exogenous factors that induce oxidative modifications leading to mutations and genomic instability.
Adnan Ayna, Cuneyt Caglayan, Seyithan Taysi   +2 more
doaj   +1 more source

Biochemical reconstitution and genetic characterization of the major oxidative damage base excision DNA repair pathway in Thermococcus kodakarensis

, 2019
Alexandra M. Gehring, Kelly M. Zatopek, Brett W. Burkhart, В. А. Потапов, Thomas J. Santangelo, Andrew F. Gardner   +5 more
openalex   +1 more source

Ischemic Preconditioning in the Rat Brain Enhances the Repair of Endogenous Oxidative DNA Damage by Activating the Base-Excision Repair Pathway [PDF]

, 2005
Wenjin Li, Yumin Luo, Feng Zhang, Armando P. Signore, Glenn T. Gobbel, Roger P. Simon, Jun Chen   +6 more
openalex   +1 more source

Participation of RecJ in the base excision repair pathway of Deinococcus radiodurans [PDF]

, 2020
Kaiying Cheng, Ying Xu, Xuanyi Chen, Huizhi Lu, Yuan He, Liangyan Wang, Yuejin Hua   +6 more
openalex   +1 more source