Results 151 to 160 of about 967,825 (378)

Recognition and Repair of Compound DNA Lesions (Base Damage and Mismatch) by Human Mismatch Repair and Excision Repair Systems [PDF]

, 1997
David Mu, Mihray Tursun, Derek R. Duckett, James T. Drummond, Paul Modrich, Aziz Sancar   +5 more
openalex   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Replication Protein A Stimulates Long Patch DNA Base Excision Repair [PDF]

, 1998
Michael S. DeMott, Seymour Zigman, Robert A. Bambara   +2 more
openalex   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Distance-Based Approaches to Repair Semantics in Ontology-based Data Access [PDF]

arXiv, 2019
In the presence of inconsistencies, repair techniques thrive to restore consistency by reasoning with several repairs. However, since the number of repairs can be large, standard inconsistent tolerant semantics usually yield few answers. In this paper, we use the notion of syntactic distance between repairs following the intuition that it can allow us ...
arxiv  

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Nature Communications, 2016
The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during ...
Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu   +6 more
doaj   +1 more source

Mammalian Abasic Site Base Excision Repair [PDF]

, 1998
Deepak Srivastava, Brian J. Vande Berg, Rajendra Prasad, J. Thomas Molina, William A. Beard, Alan E. Tomkinson, Samuel H. Wilson   +6 more
openalex   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Counterexample-Guided Repair of Reinforcement Learning Systems Using Safety Critics [PDF]

arXiv
Naively trained Deep Reinforcement Learning agents may fail to satisfy vital safety constraints. To avoid costly retraining, we may desire to repair a previously trained reinforcement learning agent to obviate unsafe behaviour. We devise a counterexample-guided repair algorithm for repairing reinforcement learning systems leveraging safety critics. The
arxiv  

Exploiting System Hierarchy to Compute Repair Plans in Probabilistic Model-based Diagnosis [PDF]

arXiv, 2013
The goal of model-based diagnosis is to isolate causes of anomalous system behavior and recommend inexpensive repair actions in response. In general, precomputing optimal repair policies is intractable. To date, investigators addressing this problem have explored approximations that either impose restrictions on the system model (such as a single fault
arxiv