Results 261 to 270 of about 64,997 (303)
HMGB2 is a biomarker associated with poor prognosis promoting radioresistance in glioma by targeting base excision repair pathway. [PDF]
Transl OncolHan W +7 more
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Base excision repair and cancer [PDF]
Cancer Letters, 2012 Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer.
Susan S Wallace +2 more
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Monitoring base excision repair by in vitro assays
Toxicology, 2003 Base excision repair (BER) is the major mechanism for processing of mutagenic and genotoxic DNA base lesions caused by cellular environmental or exogenous mutagens. In vitro base excision repair assays have been used in studies aimed at understanding the
Grigory L Dianov
exaly +2 more sources
A role for p53 in base excision repair [PDF]
EMBO Journal, 2001 Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components or in extracts of cells. In contrast, p53 with missense mutations either at hot-spots in the core domain or within the N-terminal transactivation domain is defective in this function.
Jinwoo Ahn +2 more
exaly +3 more sources
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2006
From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
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From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
openaire +4 more sources
The base excision repair pathway
Trends in Biochemical Sciences, 1995The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating ...
E, Seeberg, L, Eide, M, Bjørås
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Mitochondrial Base Excision Repair Assays
2012Mitochondrial DNA (mtDNA) is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to be particularly deleterious in post-mitotic cells, including neurons ...
Gredilla, Ricardo +1 more
openaire +3 more sources
Cellular and Molecular Life Sciences, 2008
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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Targeting Base Excision Repair for Chemosensitization
Anti-Cancer Agents in Medicinal Chemistry, 2008In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in the clinic have the ability to induce
Sanjay, Adhikari +5 more
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Base excision repair in yeast and mammals
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA damages. Many of these damages arise spontaneously because DNA interacts with the cellular milieu, and so BER profoundly influences spontaneous mutation rates. In addition, BER
L Samson
exaly +3 more sources