Results 271 to 280 of about 64,997 (303)
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Base excision repair in nucleosome substrates
Chromosome Research, 2006Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with ...
Indu, Jagannathan +2 more
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Enzymology of mitochondrial base excision repair
2001A number of laboratories have shown that those types of DNA damage that are generally reparable by base excision repair are efficiently repaired in mtDNA. In contrast, most types of damage that require other sorts of repair machinery are not effectively repaired in mtDNA.
D F, Bogenhagen +2 more
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DNA modifications repaired by base excision repair are epigenetic
DNA Repair, 2013CREB controls ∼25% of the mammalian transcriptome. Small changes in binding to its consensus (CRE) sequence are likely to be amplified many fold in initiating transcription. Here we show that DNA lesions repaired by the base excision repair (BER) pathway modulate CREB binding to CRE. We generated Kd values by electrophoretic mobility shift assays using
Stephen P G, Moore +2 more
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Analysis of base excision and nucleotide excision repair in Candida albicans
Microbiology, 2008Candida albicans, clinically the most important human fungal pathogen, rapidly develops resistance to antifungal drugs. The acquisition of resistance has been linked to various types of genome changes. As part of an ongoing study of this problem, we investigated mutation, genome stability and drug resistance acquisition in C.
Melanie, Legrand +3 more
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Base Excision Repair in Mammalian Cells
2008A rapid, convenient and safe in vitro assay system for base excision repair is described. Whole cell extracts are prepared by detergent-based cell lysis and provide a vigorous activity of AP site repair. A circular DNA substrate is used for detection of both DNA polymerase beta-dependent and proliferating cell nuclear antigen (PCNA)-dependent pathways.
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XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
Molecular Cell, 2021Kouji Hirota +2 more
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