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Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway. [PDF]
MutagenesisAlmohdar D +7 more
europepmc +1 more source
Base Excision Repair and Cancer [PDF]
Cancer Letters, 2012 Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer.
Susan S Wallace +2 more
exaly +3 more sources
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2006
From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
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From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
openaire +4 more sources
The base excision repair pathway
Trends in Biochemical Sciences, 1995The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating ...
E, Seeberg, L, Eide, M, Bjørås
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A Role for p53 in Base Excision Repair [PDF]
EMBO Journal, 2001 Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components or in extracts of cells. In contrast, p53 with missense mutations either at hot-spots in the core domain or within the N-terminal transactivation domain is defective in this function.
Samuel H. Wilson +2 more
exaly +3 more sources
Mammalian Base Excision Repair: The Forgotten Archangel. [PDF]
Nucleic Acids Research, 2013 Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens.
Grigory L Dianov, Ulrich Hübscher
exaly +6 more sources
Mitochondrial Base Excision Repair Assays
2012Mitochondrial DNA (mtDNA) is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to be particularly deleterious in post-mitotic cells, including neurons ...
Gredilla, Ricardo +1 more
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Cellular and Molecular Life Sciences, 2008
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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Targeting Base Excision Repair for Chemosensitization
Anti-Cancer Agents in Medicinal Chemistry, 2008In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in the clinic have the ability to induce
Sanjay, Adhikari +5 more
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