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, 2006 From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
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The base excision repair pathway
Trends in Biochemical Sciences, 1995The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating ...
Lars Eide +3 more
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Base excision and nucleotide excision repair pathways in mycobacteria
Tuberculosis, 2011About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount ...
Umesh Varshney +2 more
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Base Excision Repair of DNA: Glycosylases [PDF]
Russian Journal of Genetics, 2005 The review considers the role of base excision repair in maintaining the constancy of genetic information in the cell. The genetic control and biochemical mechanism are described for the first stage of base excision repair, which is catalyzed by specific enzymes, DNA glycosylases.
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Cellular and Molecular Life Sciences, 2008
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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Mitochondrial Base Excision Repair Assays
2012Mitochondrial DNA (mtDNA) is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to be particularly deleterious in post-mitotic cells, including neurons ...
Gredilla, Ricardo, Stevnsner, Tinna
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Base excision repair in nucleosome substrates
Chromosome Research, 2006Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with ...
Indu Jagannathan +2 more
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Targeting Base Excision Repair for Chemosensitization
Anti-Cancer Agents in Medicinal Chemistry, 2008In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in the clinic have the ability to induce
Rabindra Roy +5 more
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Base excision repair in yeast and mammals
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA damages. Many of these damages arise spontaneously because DNA interacts with the cellular milieu, and so BER profoundly influences spontaneous mutation rates. In addition, BER
Asli Memisoglu, Leona D. Samson
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Analytical Chemistry, 2016
DNA glycosylase is an initiating enzyme of cellular base excision repair pathway which is responsible for the repair of various DNA lesions and the maintenance of genomic stability, and the dysregulation of DNA glycosylase activity is associated with a ...
Li-juan Wang +3 more
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DNA glycosylase is an initiating enzyme of cellular base excision repair pathway which is responsible for the repair of various DNA lesions and the maintenance of genomic stability, and the dysregulation of DNA glycosylase activity is associated with a ...
Li-juan Wang +3 more
semanticscholar +1 more source