Results 341 to 350 of about 967,825 (378)
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Enzymology of mitochondrial base excision repair
2001A number of laboratories have shown that those types of DNA damage that are generally reparable by base excision repair are efficiently repaired in mtDNA. In contrast, most types of damage that require other sorts of repair machinery are not effectively repaired in mtDNA.
Romina M. Perez-Jannotti +2 more
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DNA modifications repaired by base excision repair are epigenetic
DNA Repair, 2013CREB controls ∼25% of the mammalian transcriptome. Small changes in binding to its consensus (CRE) sequence are likely to be amplified many fold in initiating transcription. Here we show that DNA lesions repaired by the base excision repair (BER) pathway modulate CREB binding to CRE. We generated Kd values by electrophoretic mobility shift assays using
Kimberly J. Toomire +2 more
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Base Excision Repair in Mammalian Cells
2008A rapid, convenient and safe in vitro assay system for base excision repair is described. Whole cell extracts are prepared by detergent-based cell lysis and provide a vigorous activity of AP site repair. A circular DNA substrate is used for detection of both DNA polymerase beta-dependent and proliferating cell nuclear antigen (PCNA)-dependent pathways.
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Analysis of base excision and nucleotide excision repair in Candida albicans
Microbiology, 2008Candida albicans, clinically the most important human fungal pathogen, rapidly develops resistance to antifungal drugs. The acquisition of resistance has been linked to various types of genome changes. As part of an ongoing study of this problem, we investigated mutation, genome stability and drug resistance acquisition in C.
Peter A. Jauert +3 more
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Cell Biochemistry and Function, 2010
Lack of reliable assays for DNA repair has largely prevented measurements of DNA repair from being included in human biomonitoring studies. Using newly developed modifications of the comet assay we tested whether a fruit- and antioxidant-rich plant-based intervention could affect base excision repair (BER) and nucleotide excision repair (NER) in a ...
Rune Blomhoff +5 more
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Lack of reliable assays for DNA repair has largely prevented measurements of DNA repair from being included in human biomonitoring studies. Using newly developed modifications of the comet assay we tested whether a fruit- and antioxidant-rich plant-based intervention could affect base excision repair (BER) and nucleotide excision repair (NER) in a ...
Rune Blomhoff +5 more
openaire +3 more sources
1981
The terms base excision repair (BER) and nucleotide excision repair (NER) were first suggested by Duncan et al in 1976 (1), since at that time distinct modes of excision repair appeared distinguishable by a least two criteria.
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The terms base excision repair (BER) and nucleotide excision repair (NER) were first suggested by Duncan et al in 1976 (1), since at that time distinct modes of excision repair appeared distinguishable by a least two criteria.
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Base-Excision Repair: Role of DNA Polymerase β in Late-Stage Base Excision Repair
2010The cellular DNA repair pathway known as base-excision repair is responsible for removing toxic base lesions and strand breaks from genomic and mitochondrial DNA. The base-excision repair pathway is conserved in organisms throughout nature, but there are many variations probably reflecting the broad range of genotoxic stresses encountered and the gene ...
Samuel H. Wilson, Kenjiro Asagoshi
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Mammalian DNA base excision repair: Dancing in the moonlight.
DNA Repair, 2020K. Caldecott
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Base excision repair gets a refit
Trends in Biochemical Sciences, 2002DNA contains the genetic information for life, and so must be carefully maintained. Base excision repair (BER) of DNA is the process used to repair single base mismatches. The process is initiated by a DNA glycosylase, which removes the base from a mismatch, leaving a site without a base [an apurinic or apyrimidinic (AP) site]. AP endonuclease 1 (APE1)
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BASE-EXCISION REPAIR IN MICROCOCCUS LUTEUS
1978ABSTRACT Base-excision repair of DNA damaged by chemicals relies upon the sequential action of specific DNA-glycosylases wich excises the modified bases yielding an apurinic or apyrimidinic site. This site is in turn recognised by a specific endonuclease wich hydrolyse the phosphodiester bond of DNA adjacent to this site.
Josiane Pierre, Jacques Laval
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