Results 51 to 60 of about 64,874 (247)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Base Nacional Comum Curricular e novo ensino médio

Revista Histedbr On-line, 2020
Este artigo apresenta resultados parciais de pesquisa de cunho documental-bibliográfico, dedicada à compreensão dos pormenores da Base Nacional Comum Curricular (BNCC) e do Novo Ensino Médio (NEM) em diálogo com os aspectos histórico-estruturantes da ...
Maria Carolina Pires de Andrade, Vânia Cardoso da Motta   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Educação Básica: Base Nacional Comum e infraestrutura escolar

Dialogia, 2016
A discussão atual sobre a Base Nacional Comum é legitima quando a questão é tornar a escola mais democrática e de qualidade. No entanto, espera-se que suas consequências não ampliem ainda mais o controle e a pressão sobre as escolas e professores.
Paulo Sérgio Garcia, Leandro Campi Prearo, Maria Carmo Romeiro   +2 more
doaj   +1 more source

A BASE NACIONAL COMUM CURRICULAR E A POLÍTICA NACIONAL DE ALFABETIZAÇÃO

Poiésis - Revista do Programa de Pós-Graduação em Educação
The present study aimed to analyze the three editions of the Common National Curricular Base (BRASIL, 2015; 2016; 2017), the National Literacy Policy (BRASIL, 2019) and the (dis)articulation with contemporary policies in this area, in our country. This is a qualitative investigation (GIL, 2008; MINAYO, 2001), whose research techniques were based on ...
Ana Kátia Da Costa Silva, Solange Alves de Oliveira-Mendes   +1 more
openaire   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Análise da educação brasileira em face ao estudo da sexualidade

Doxa, 2022
O presente trabalho visa analisar a marginalização da Educação Sexual na Base Nacional Comum Curricular (BNCC) em face aos preceitos de educação, das políticas públicas existentes e dos princípios de cidadania existentes e garantidos aos cidadãos. Busca-
Thiago Luiz Sartori
doaj  

Letramento Crítico na Base Nacional Comum Curricular:

Kiri-Kerê - Pesquisa em Ensino, 2022
O objetivo deste artigo é analisar três Competências Específicas que atravessam as habilidades preconizadas para o ensino-aprendizagem de Língua Portuguesa, a fim de verificar como os princípios do Letramento Crítico se revelam no documento normativo.
openaire   +1 more source