Results 71 to 80 of about 64,874 (247)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Alfabetização na Base Nacional Comum Curricular (BNCC)

Pro-Posições
Resumo Este artigo tem por objetivo analisar como a alfabetização é articulada na Base Nacional Comum Curricular (BNCC) aprovada pelo Conselho Nacional de Educação em dezembro de 2017.
Cláudia Maria Mendes Gontijo, Dania Monteiro Vieira Costa, Nayara Santos Perovano   +2 more
doaj   +2 more sources

BASE NACIONAL COMUM CURRICULAR - BNCC COMPONENTE CURRICULAR: GEOGRAFIA

Revista da ANPEGE, 2017
O artigo analisa a Base Nacional Comum Curricular (BNCC), tornada pública pelo Ministério da Educação em 2016. A Constituição Federal de 1988, construída nas mobilizações sindicais e sociais da década de 1980, estabeleceu a criação de conteúdos mínimos ...
Marcos Antonio Campos Couto
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Educação ambiental na base nacional comum curricular [PDF]

Revista Brasileira de Educação em Ciências e Educação Matemática, 2020
A presente resenha debruça-se sobre a obra: “A BNCC da Educação Infantil ao Ensino Fundamental: políticas públicas, currículo, competências e Educação Ambiental” de autoria da pesquisadora Silvana do Nascimento Silva, professora titular do Departamento de Ciências Biológicas da Universidade Estadual do Sudoeste da Bahia.
openaire   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

An approach to the Urgencies and Emergencies Medicine

Medisan, 2018
A study on the development of the Urgencies and Emergencies Medicine, its main concepts and peculiarities is carried out. The current pattern of the SIUM  in Cuba is approached, which has been the solution to the severely-ill patient and it has allowed ...
Jorge Luis Sánchez Guillaume
doaj  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

(Re)conhecendo a Base Nacional Comum Curricular:

Educação em Foco
Neste texto, tenciona-se analisar a estrutura da Base Nacional Comum Curricular (BNCC), visto ser o documento que estrutura toda a educação nacional. Para tanto, inicia-se por balizar o projeto de cultura da Base mediante o histórico e então a estrutura dessas diretrizes curriculares e, por fim, refletir sobre as bases ideológicas em que se firmam ...
Andressa da Silva Gonçalves, Wilma De Nazaré Baía COELHO   +1 more
openaire   +1 more source