Results 61 to 70 of about 71,553 (287)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
AS PRÁTICAS DE ENSINAGEM DE LÍNGUA PORTUGUESA E A BASE NACIONAL COMUM CURRICULAR
, 2023 As atividades de ensino e aprendizagem tornam-se pontos essenciais de partida das reflexões destas com as finalidades de discutir a relevância da Base Nacional Comum Curricular (BNCC) como documento oficial; correlacionar as discussões na BNCC com as ...
Sousa, Ivan Vale de
core +2 more sources
BASE NACIONAL COMUM CURRICULAR (BNCC)
Revista Espaço do CurrículoO estudo investiga a formação de professores no Brasil a partir da Base Nacional Comum Curricular (BNCC) e de documentos que se ramificam dela como a Base Nacional Comum para a Formação Inicial de Professores da Educação Básica (BNC-Formação). Objetiva analisar como a BNCC afeta a educação escolar com foco sobre as diretrizes estabelecidas para a ...
Expedito Vital Marinho Junior +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Letramento Crítico na Base Nacional Comum Curricular:
Kiri-Kerê - Pesquisa em Ensino, 2022 O objetivo deste artigo é analisar três Competências Específicas que atravessam as habilidades preconizadas para o ensino-aprendizagem de Língua Portuguesa, a fim de verificar como os princípios do Letramento Crítico se revelam no documento normativo.
openaire +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source