Results 41 to 50 of about 28,547,466 (259)
Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation
Nature Communications, 2016 Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position ...
Franck Martin +8 more
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Pre-mRNA splicing is a determinant of nucleosome organization. [PDF]
PLoS ONE, 2013 Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed
Hadas Keren-Shaul +2 more
doaj +1 more source
Base Pairing Promoted the Self-Organization of Genetic Coding, Catalysis, and Free-Energy Transduction. [PDF]
Life (Basel)How Nature discovered genetic coding is a largely ignored question, yet the answer is key to explaining the transition from biochemical building blocks to life. Other, related puzzles also fall inside the aegis enclosing the codes themselves. The peptide
Carter CW.
europepmc +2 more sources
Molecules, 2023 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5′-monophosphate (ZMP) is a central intermediate in de novo purine nucleotide biosynthesis. Its nucleobase moiety, 5-aminoimidazole-4-carboxamide (Z-base), is considered an ambiguous base that can pair ...
Yuhei Nogi +3 more
doaj +1 more source
Life, 2020 It is possible that early life relied on RNA polymers that served as ribozyme-like catalysts and for storing genetic information. The source of such polymers is uncertain, but previous investigations reported that wet–dry cycles simulating prebiotic hot ...
Tue Hassenkam +3 more
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Base pairing and structural insights into the 5-formylcytosine in RNA duplex
Nucleic Acids Research, 2016 5-Formylcytidine (f5C), a previously discovered natural nucleotide in the mitochondrial tRNA of many species including human, has been recently detected as the oxidative product of 5-methylcytidine (m5C) through 5-hydroxymethylcytidine (hm5C) in total ...
Rui Wang +5 more
semanticscholar +1 more source
ACS Chemical Biology, 2016 In the active cytosine demethylation pathway, 5-methylcytosine (5mC) is oxidized sequentially to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Thymine DNA glycosylase (TDG) selectively excises 5fC and 5caC but not
Qing Dai +5 more
semanticscholar +1 more source
Partition function and base pairing probabilities of RNA heterodimers
Algorithms for Molecular Biology, 2006 Background RNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function by binding to other nucleic acids, as in the case of microRNAs and snoRNAs.
Stadler Peter F +5 more
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Artificial DNA Base Pairing Mediated by Diverse Metal Ions
, 2017 Metal-mediated artificial DNA base pairs, consisting of two ligand-type nucleosides and a bridging metal ion, are promising building units for constructing DNA-based supermolecules.
Yusuke Takezawa +2 more
semanticscholar +1 more source
How do base-pairing small RNAs evolve?
FEMS Microbiology Reviews, 2015 The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the identification of these regulators in a broad range of bacteria are allowing comparisons between species and explorations of sRNA evolution.
T. Updegrove, S. Shabalina, G. Storz
semanticscholar +1 more source