Results 41 to 50 of about 32,528,266 (371)
Enzyme-free genetic copying of DNA and RNA sequences
Beilstein Journal of Organic Chemistry, 2018 The copying of short DNA or RNA sequences in the absence of enzymes is a fascinating reaction that has been studied in the context of prebiotic chemistry.
Marilyne Sosson, Clemens Richert
doaj +1 more source
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]
, 2006 Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas +5 more
core +1 more source
Coupled dynamics of RNA folding and nanopore translocation [PDF]
, 2005 The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base-pairing theoretically, using kinetic Monte Carlo simulations
B. Alberts +4 more
core +2 more sources
Life, 2019 A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
doaj +1 more source
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation
eLife, 2020 By shaping gene expression profiles, small RNAs (sRNAs) enable bacteria to efficiently adapt to changes in their environment. To better understand how Escherichia coli acclimatizes to nutrient availability, we performed UV cross-linking, ligation and ...
Ira Alexandra Iosub +8 more
doaj +1 more source
Evaluation of RNA secondary structure prediction for both base-pairing and topology
Biophysics Reports, 2018 Graphical abstractAbstractSecondary structures of RNAs are crucial to the understanding of their tertiary structures and functions. At present, many theoretical methods are widely used to predict RNA secondary structures. The performance of these methods
Yunjie Zhao +3 more
semanticscholar +1 more source
Pre-mRNA splicing is a determinant of nucleosome organization. [PDF]
PLoS ONE, 2013 Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed
Hadas Keren-Shaul +2 more
doaj +1 more source
ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. [PDF]
, 2014 Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5'-terminal nucleotide is important for sRNA sorting into different AGOs.
Carbonell, Alberto +9 more
core +2 more sources
ACS Omega, 2017 Chemical modifications of 2′-O-methyl (2′-OMe) and locked nucleic acid (LNA) of the nucleotides in the seed region (positions 2–8) of the small interfering RNA (siRNA) guide strand significantly reduced seed-matched (SM) off-target effects.
Hanna Iribe +6 more
semanticscholar +1 more source
Manipulating a single adsorbed DNA for a critical endpoint [PDF]
, 2008 We show the existence of a critical endpoint in the phase diagram of unzipping of an adsorbed double-stranded (ds) polymer like DNA. The competition of base pairing, adsorption and stretching by an external force leads to the critical end point.
Bhattacharjee S. M. +9 more
core +2 more sources