Capturing alternative secondary structures of RNA by decomposition of base-pairing probabilities
Background It is known that functional RNAs often switch their functions by forming different secondary structures. Popular tools for RNA secondary structures prediction, however, predict the single ‘best’ structures, and do not produce alternative ...
Taichi Hagio+4 more
doaj +1 more source
Orthogonal Base Pairs Continue to Evolve [PDF]
Recent developments in the design and construction of unusual analogs of the natural nucleic acid bases have reached a milestone with the report (in this issue of Chemistry & Biology) of a new orthogonal base pair that allows site-specific introduction of a photo-crosslinkable modified base into an RNA molecule by T7 RNA polymerase-mediated ...
openaire +3 more sources
A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
N 6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pairs and
Bei Liu+8 more
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Attribute-based encryption (ABE) is used for achieving data confidentiality and access control in cloud environments. Most often ABE schemes are constructed using bilinear pairing which has a higher computational complexity, making algorithms inefficient
Balaji Chandrasekaran+1 more
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On randomization-based causal inference for matched-pair factorial designs [PDF]
Under the potential outcomes framework, we introduce matched-pair factorial designs, and propose the matched-pair estimator of the factorial effects. We also calculate the randomization-based covariance matrix of the matched-pair estimator, and provide the "Neymanian" estimator of the covariance matrix.
arxiv
Synthetic Spectroscopic Models Related to Coenzymes and Base Pairs, VII. Stacking Interactions in tRNA; the „Bend” at Dimethylguanosine [PDF]
Hajime Iwamura+2 more
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The tandem repeat stretches of cytosine residues fold to construct intercalated motif (i-motif) structures over an acidic pH range. Several advancements have been made to understand the biological role of i-motif DNA.
Swati Chaudhary+3 more
doaj
Base-pairing versatility determines wobble sites in tRNA anticodons of vertebrate mitogenomes.
BackgroundVertebrate mitochondrial genomes typically have one transfer RNA (tRNA) for each synonymous codon family. This limited anticodon repertoire implies that each tRNA anticodon needs to wobble (establish a non-Watson-Crick base pairing between two ...
Miguel M Fonseca+2 more
doaj +1 more source
Impurity effect as a probe for the pairing symmetry of graphene-based superconductors [PDF]
The single impurity effect on the graphene-based superconductor is studied theoretically. Four different pairing symmetries are discussed. Sharp resonance peaks are found near the impurity site for the $d+id$-wave pairing symmetry and the $p+ip$-wave pairing symmetry when the chemical potential is large.
arxiv
Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. [PDF]
Heinz L. Sänger+4 more
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