Results 101 to 110 of about 2,847,295 (322)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action. [PDF]
Genes Genomics, 2022 Inokuchi H.
europepmc +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
IVisTMSA: Interactive Visual Tools for Multiple Sequence Alignments
Evolutionary Bioinformatics, 2015 IVisTMSA is a software package of seven graphical tools for multiple sequence alignments. MSApad is an editing and analysis tool. It can load 409% more data than Jalview, STRAP, CINEMA, and Base-by-Base.
Muhammad Tariq Pervez +10 more
doaj +1 more source
Partial mitochondrial genome of Indian rose-ringed parakeet (Psittacula krameri) from India
Mitochondrial DNA. Part B. Resources, 2020 Indian rose-ringed parakeet (Psittacula krameri) is one of the most recognizable illegally trafficked wild birds. With feral populations in Europe and Australia, its phylogeny and taxonomy are of great interest amongst biologists.
Machaiah Periyanda Nachappa +5 more
doaj +1 more source
, 2011 We introduce the intuitive method to select an analytic Abel function of an analytic function f at a non-fixpoint. Due to the complexity of this method by involving matrix inversion of increasing size there is little known about its convergence.
Trappmann, Henryk
core
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates
Nature CommunicationsNature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively ...
Sumit Majumder +3 more
doaj +1 more source
The elemental mechanism of transcriptional pausing. [PDF]
, 2019 Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise.
Chua, Xien Yu +6 more
core +1 more source