Results 111 to 120 of about 2,847,295 (322)

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

open access: yesFEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter   +8 more
wiley   +1 more source

Mixed Sequence Reader: A Program for Analyzing DNA Sequences with Heterozygous Base Calling

open access: yesThe Scientific World Journal, 2012
The direct sequencing of PCR products generates heterozygous base-calling fluorescence chromatograms that are useful for identifying single-nucleotide polymorphisms (SNPs), insertion-deletions (indels), short tandem repeats (STRs), and paralogous genes ...
Chun-Tien Chang   +10 more
doaj   +1 more source

Integrated sequence display device [PDF]

open access: yes, 1969
Device integrates a planned test sequence with real-time changes indicated on a visual display which includes a record of both planned and unplanned events related to a time base.
Rosine, D. R.
core   +1 more source

Gröbner Bases for Increasing Sequences

open access: yesThe Electronic Journal of Combinatorics
Let $q,n \geq 1$ be integers, $[q]=\{1,\ldots, q\}$, and $F$ be a field with $|F|\geq q$. The setof increasing sequences $$I(n,q)=\{(f_1,f_2, \dots, f_n) \in [q]^n:~ f_1\leq f_2\leq\cdots \leq f_n \}$$can be mapped via an injective map $i: [q]\rightarrow F $ into a subset $J(n,q)$ of the affine space $F^n$.
Hegedüs, Gábor, Rónyai, Lajos
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

PCR Mutagenesis-Based Method for Generation of Positive Controls for SSCP Analysis

open access: yesBioTechniques, 1997
We have developed a primer-mediated PCR mutagenesis-based method for the generation of positive controls to test the sensitivity of single-strand conformation polymorphism (SSCP) or any other PCRbased mutation screening method. This technique is based on
A. Ruiz   +4 more
doaj   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

open access: yesFEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu   +5 more
wiley   +1 more source

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