Results 11 to 20 of about 842,010 (246)
Base Sequence Context Effects on Nucleotide Excision Repair [PDF]
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
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Sequence-Based Linkage Analysis [PDF]
The American Journal of Human Genetics, 2004 The rapid decrease in the cost of DNA sequencing will enable its use for novel applications. Here, we investigate the use of DNA sequencing for simultaneous discovery and genotyping of polymorphisms in family linkage studies. In the proposed approach, short contiguous segments of genomic DNA, regularly spaced across the genome, are resequenced in each ...
Dana P. Carrington +7 more
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Feature-Based Sequence-to-Sequence Matching [PDF]
International Journal of Computer Vision, 2006 This paper studies the problem of matching two unsynchronized video sequences of the same dynamic scene, recorded by different stationary uncalibrated video cameras. The matching is done both in time and in space, where the spatial matching can be modeled by a homography (for 2D scenarios) or by a fundamental matrix (for 3D scenarios).
Denis Simakov, Michal Irani, Yaron Caspi
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Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity
Molecular Therapy: Nucleic Acids, 2023 Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology.
Kai Cheng +14 more
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Contact-based sequence alignment [PDF]
Nucleic Acids Research, 2004 This paper introduces the novel method of contact-based protein sequence alignment, where structural information in the form of contact mutation probabilities is incorporated into an alignment routine using contact-mutation matrices (CAO: Contact Accepted mutatiOn).
Kuang Lin +3 more
openaire +4 more sources
Enteropathogenic Escherichia coli O157 Strains from Brazil
Emerging Infectious Diseases, 2003 We describe two serogroup O157 Escherichia coli strains from Brazilian infants with diarrhea. A variety of assays indicate that these strains belong to the enteropathogenic, not the enterohemorrhagic, pathotype.
T. Eric Blank +5 more
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Sequence dependency of canonical base pair opening in the DNA double helix. [PDF]
PLoS Computational Biology, 2017 The flipping-out of a DNA base from the double helical structure is a key step of many cellular processes, such as DNA replication, modification and repair.
Viveca Lindahl +2 more
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Knowledge Modeling in Troubleshooting
Инженерные технологии и системы, 2021 Introduction. The article describes the approach to solving the problem of complex technical system troubleshooting based on expert knowledge modeling.
Valeriy P. Dimitrov +2 more
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Molecular Epidemiology of O139 Vibrio cholerae: Mutation, Lateral Gene Transfer, and Founder Flush
Emerging Infectious Diseases, 2003 Vibrio cholerae in O-group 139 was first isolated in 1992 and by 1993 had been found throughout the Indian subcontinent. This epidemic expansion probably resulted from a single source after a lateral gene transfer (LGT) event that changed the serotype of
Pallavi Garg +5 more
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Local alignment of two-base encoded DNA sequence
BMC Bioinformatics, 2009 Background DNA sequence comparison is based on optimal local alignment of two sequences using a similarity score. However, some new DNA sequencing technologies do not directly measure the base sequence, but rather an encoded form, such as the two-base ...
Merriman Barry +2 more
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