Results 41 to 50 of about 905,353 (315)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Nucleotide Sequence-Based Multitarget Identification [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACTMULTIGEN technology (T. Vinayagamoorthy, U.S. patent 6,197,510, March 2001) is a modification of conventional sequencing technology that generates a single electropherogram consisting of short nucleotide sequences from a mixture of known DNA targets. The target sequences may be present on the same or different nucleic acid molecules.
T, Vinayagamoorthy +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 The complete mitochondrial genome of tufted deer (Elaphodus cephalophus) has been described in our research. The sequence of this genome is 16356 bp with a circular structure, and contains 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two
Lin Zhang +10 more
doaj +1 more source
BMC Bioinformatics, 2020 Background Repertoire analysis of patient-derived recombinant monoclonal antibodies is an important tool to study the role of B cells in autoimmune diseases of the human brain and beyond.
S. Momsen Reincke +2 more
doaj +1 more source
Sequence-dependent nucleosome sliding in rotation-coupled and uncoupled modes revealed by molecular simulations. [PDF]
PLoS Computational Biology, 2017 While nucleosome positioning on eukaryotic genome play important roles for genetic regulation, molecular mechanisms of nucleosome positioning and sliding along DNA are not well understood.
Toru Niina +3 more
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Entering the post-genomic era of malaria research
Bulletin of the World Health Organization, 2000 The sequencing of the genome of Plasmodium falciparum promises to revolutionize the way in which malaria research will be carried out. Beyond simple gene discovery, the genome sequence will facilitate the comprehensive determination of the parasite?s ...
Horrocks Paul +4 more
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Research of Dynamic Wide-gap Frequency Hopping Sequences in Dynamic Spectrum Anti-jamming System [PDF]
Jisuanji gongcheng, 2018 The existing Frequency Hopping(FH) sequence can not be directly applied to a dynamic spectrum anti-interference system due to poor statistical performance and difficulty in real-time changes of communication parameters.Therefore,a FH sequence suitable ...
LI Shengnan,LI Yonggui,NIU Yingtao,YAN Yan,LUO Jianxiang
doaj