Results 101 to 110 of about 2,107,603 (337)

Transmission electron microscopy analysis of epithelial basement membrane repair in rabbit corneas with haze.

Investigative Ophthalmology and Visual Science, 2013
PURPOSE To assess the ultrastructure of the epithelial basement membrane using transmission electron microscopy (TEM) in rabbit corneas with and without subepithelial stroma opacity (haze). METHODS Two groups of eight rabbits each were included in this
A. Torricelli, Vivek Singh, V. Agrawal, M. Santhiago, S. Wilson   +4 more
semanticscholar   +1 more source

ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis

BMC Nephrology
Background Diabetic nephropathy (DN) and atherosclerosis (AS) are prevalent and severe complications associated with diabetes, exhibiting lesions in the basement membrane, an essential component found within the glomerulus, tubules, and arteries.
Yude Lou, Peng Hui Li, Xiao Qi Liu, Tian Xiang Wang, Yi Lan Liu, Chen Chen Chen, Kun Ling Ma   +6 more
doaj   +1 more source

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications

Advanced Healthcare Materials, EarlyView.
Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor, Ian Woods, Sarah F. McComish, Sean Kerr, Matthew McGrath, Juan Carlos Palomeque Chávez, Jack Maughan, Tara McGuire, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +10 more
wiley   +1 more source

Superficial dermal fibroblasts enhance basement membrane and epidermal barrier formation in tissue-engineered skin: implications for treatment of skin basement membrane disorders.

Tissue Engineering. Part A, 2013
Basement membrane is a highly specialized structure that binds the dermis and the epidermis of the skin, and is mainly composed of laminins, nidogen, collagen types IV and VII, and the proteoglycans, collagen type XVIII and perlecan, all of which play ...
M. Varkey, Jie Ding, E. Tredget
semanticscholar   +1 more source

The basement membrane zone of the nail

British Journal of Dermatology, 2006
The anatomy of the epidermis, dermis and subcutaneous tissues of the nail apparatus is distinct from that of non-appendageal skin. Apart from the demonstration of the longitudinal configuration of the dermal-epidermal junction of the nail bed, there have been no studies of the composition of the basement membrane zone of the nail apparatus. We obtained
Sinclair, R, Wojnarowska, F, Leigh, I, Dawber, R   +3 more
openaire   +4 more sources

Pathological MAPK activation–mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib

JCI Insight, 2022
Lymphangiectasia, an anomalous dilation of lymphatic vessels first described in the 17th century, is frequently associated with chylous effusion, respiratory failure, and high mortality in young patients, yet the underlying molecular pathogenesis and ...
Harish P. Janardhan, Karen Dresser, Lloyd Hutchinson, Chinmay M. Trivedi   +3 more
doaj   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Advanced Materials, EarlyView.
Dynamic nanoscale groove‐ridge structures are engineered by flexibly conjugating RGD‐magnetic nanoparticles to nanogroove templates with variable groove widths at the molecular scale. Magnetic control enables cyclic switching between nanoscale groove and ridge states that modulates ligand accessibility of cellular integrins.
Hyunsik Hong, Dahee Kim, Hwapyung Jung, Seongyeol Kim, Sunhong Min, Chowon Kim, Kanghyeon Kim, Hyunji Rha, Heemin Kang   +8 more
wiley   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures

Journal of Cell Biology, 1988
We have defined a signal responsible for the morphological differentiation of human umbilical vein and human dermal microvascular endothelial cells in vitro.
Yasuo Kubota, H. Kleinman, G. Martin, T. Lawley   +3 more
semanticscholar   +1 more source