Results 71 to 80 of about 3,706,301 (294)
Collagen IV Diseases: A Focus on the Glomerular Basement Membrane in Alport Syndrome
Matrix Biology, 2016 Alport syndrome is the result of mutations in any of three type IV collagen genes, COL4A3, COL4A4, or COL4A5. Because the three collagen chains form heterotrimers, there is an absence of all three proteins in the basement membranes where they are ...
D. Cosgrove, Shi-Guang Liu
semanticscholar +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Basement membrane proteoglycans and development [PDF]
, 1993 Basement membrane proteoglycans and development. Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared.
Couchman, John R. +5 more
core +2 more sources
Correlated alterations in prostate basal cell layer and basement membrane
International Journal of Biological Sciences, 2009 Our recent studies revealed that focal basal cell layer disruption (FBCLD) induced auto-immunoreactions represented a contributing factor for human prostate tumor progression and invasion. As the basement membrane surrounds and attaches to the basal cell
Aijun Liu, Lixin Wei, William A. Gardner, Chu-Xia Deng, Yan-Gao Man
doaj
Cancer Cell International, 2009 Background MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, and growth arrest, forming acinar ...
Imbalzano Anthony N +3 more
doaj +1 more source
Force-Dependent Breaching of the Basement Membrane
Matrix Biology, 2016 Clinically, non-invasive carcinomas are confined to the epithelial side of the basement membrane and are classified as benign, whereas invasive cancers invade through the basement membrane and thereby acquire the potential to metastasize. Recent findings
Tammy T. Chang, D. Thakar, V. Weaver
semanticscholar +1 more source
Lipidomics in research on yeast membrane lipid homeostasis [PDF]
, 2017 Mass spectrometry is increasingly used in research on membrane lipid homeostasis, both in analyses of the steady state lipidome at the level of molecular lipid species, and in pulse-chase approaches employing stable isotope-labeled lipid precursors ...
de Kroon, Anton I P M +2 more
core +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
eLife, 2020 Synaptic positions underlie precise circuit connectivity. Synaptic positions can be established during embryogenesis and sustained during growth. The mechanisms that sustain synaptic specificity during allometric growth are largely unknown.
Jiale Fan +10 more
doaj +1 more source
Journal of Oral Biology and Craniofacial Research, 2022 Objectives: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status.
Anubhuti Sood +4 more
doaj +1 more source