Results 61 to 70 of about 2,517,057 (344)

Anti-glomerular basement membrane glomerulonephritis following nintedanib for idiopathic pulmonary fibrosis: a case report

Journal of Medical Case Reports, 2017
Background We report a previously unrecognized and unreported case of a patient with anti-glomerular basement membrane glomerulonephritis following nintedanib, an orally active small molecule tyrosine kinase inhibitor.
Ibrahim Ismail, Sonu Nigam, Alan Parnham, Vinay Srinivasa   +3 more
doaj   +1 more source

Anti-Glomerular Basement Membrane Disease.

American Society of Nephrology. Clinical Journal, 2017
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies ...
S. McAdoo, C. Pusey
semanticscholar   +1 more source

Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
Khoo L, Khoo, L, Payne, DN, Hansell DM, Bush, A, Saglani S, Saglani, S, Ujita, M, Jeffery, PK, Papaioannou G, Jeffery PK, Bush A, Papaioannou, G, Owens, C, Hansell, DM, Owens C, Payne DN, Owens, CM, Ujita M   +18 more
core   +1 more source

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Nature Communications, 2021
The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional ...
Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, Hironobu Fujiwara   +7 more
doaj   +1 more source

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration.

Cell Reports, 2017
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood.
Jian Song, Xueli Zhang, Konrad Buscher, Ying Wang, Huiyu Wang, Jacopo Di Russo, Lixia Li, Stefan Lütke-Enking, A. Zarbock, Anika Stadtmann, Paul Striewski, Benedikt Wirth, I. Kuzmanov, H. Wiendl, Dörte Schulte, D. Vestweber, L. Sorokin   +16 more
semanticscholar   +1 more source

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Disease Models & Mechanisms, 2016
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects.
Frances E. Jones, Matthew A. Bailey, Lydia S. Murray, Yinhui Lu, Sarah McNeilly, Ursula Schlötzer-Schrehardt, Rachel Lennon, Yoshikazu Sado, David G. Brownstein, John J. Mullins, Karl E. Kadler, Tom Van Agtmael   +11 more
doaj   +1 more source

Clinical Significance of Zero-Time Renal Transplant Biopsies and Thin Glomerular Basement Membranes in Zero-Time Renal Transplant Biopsies

Acta Clinica Croatica, 2021
Aim. To investigate morphological findings of zero-time biopsies analyzed at the Department of Nephropathology and Electron Microscopy, Dubrava University Hospital, Zagreb. Materials and methods.
Petar Šenjug, Matija Horaček, Bojana Maksimović, Ksenija Vučur, Ivica Horvatić, Nikola Zagorec, Mladen Knotek, Danica Galešić Ljubanović   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Collagens of Basement Membranes

Journal of Investigative Dermatology, 1982
Recent biochemical and immunohistochemical studies have described several components of basement membranes including heparan sulfate proteoglycan, 2 high molecular weight glycoproteins (fibronectin and laminin), and 2 collagen types (IV and V). These collagens have several properties which distinguish them from other types that are located in the ...
openaire   +2 more sources

Basement membrane mechanics shape development: Lesson from the fly

Matrix Biology, 2018
Basement membrane plays a foundational role in the structure and maintenance of many tissues throughout the animal kingdom. In addition to signaling to cells through cell-surface receptors, basement membrane directly influences the development and ...
William Ramos-Lewis, Andrea Page-McCaw
semanticscholar   +1 more source