Results 41 to 50 of about 3,706,301 (294)

Basement membrane collagens and disease mechanisms

Essays in Biochemistry, 2019
Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and collagens are a key component required for BM function. While collagen IV is the major BM collagen, collagens VI, VII, XV, XVII and XVIII are also present.
Anna Gatseva, Yan-Sin Yuan, G. Brezzo, T. Van Agtmael   +3 more
semanticscholar   +1 more source

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Nature Communications, 2017
At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma. This barrier must be breached to allow dissemination of the tumor cells to adjacent tissues.
Alexandros Glentis, P. Oertle, P. Mariani, A. Chikina, F. el Marjou, Youmna Attieh, Francois Zaccarini, M. Laé, D. Loew, F. Dingli, P. Sirven, Marie Schoumacher, Basile G. Gurchenkov, M. Plodinec, D. Vignjevic   +14 more
semanticscholar   +1 more source

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Acta Neuropathologica, 2018
Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the “glymphatic system” that proposes tracers enter the brain along periarterial “spaces” and leave the brain along the walls of veins.
Nazira J. Albargothy, D. A. Johnston, Matthew T. MacGregor-Sharp, R. Weller, A. Verma, Cheryl A. Hawkes, R. Carare   +6 more
semanticscholar   +1 more source

Anti-Glomerular Basement Membrane Disease.

American Society of Nephrology. Clinical Journal, 2017
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies ...
S. McAdoo, C. Pusey
semanticscholar   +1 more source

Anti-glomerular basement membrane glomerulonephritis following nintedanib for idiopathic pulmonary fibrosis: a case report

Journal of Medical Case Reports, 2017
Background We report a previously unrecognized and unreported case of a patient with anti-glomerular basement membrane glomerulonephritis following nintedanib, an orally active small molecule tyrosine kinase inhibitor.
Ibrahim Ismail, Sonu Nigam, Alan Parnham, Vinay Srinivasa   +3 more
doaj   +1 more source

Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology

Frontiers in Medicine, 2022
Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)2α2(IV)1 heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5 have a ...
Dominic Cosgrove, Jacob Madison
doaj   +1 more source

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]

, 2015
20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
Calvete, JJ, Rucavado Romero, Alexandra, Rucavado, A, Cristina Herrera (576490), Jéssica Kele A. Macêdo (729670), Morazan, D, Diego Morazán (729669), Mathieu-Benoit Voisin (729668), Escalante, Teresa, Libia Sanz, Mathieu-Benoit Voisin, Alexandra Rucavado (32147), Herrera, C, Macêdo, Jéssica Kele A., Jéssica Kele A Macêdo, Teresa Escalante, Calvete Chornet, Juan José, Nourshargh, S, Diego Morazán, Cristina Herrera, Voisin, Mathieu-Benoit, Voisin, M-B, Maria Gutierrez, J, Rucavado, Alexandra, Jay W Fox, José María Gutiérrez, Alexandra Rucavado, Macedo, JKA, Libia Sanz (144843), Juan J. Calvete (144840), Sanz, L, Juan J Calvete, Sussan Nourshargh (157725), Sanz, Libia, Morazán, Diego, Nourshargh, Sussan, Jay W. Fox (164576), Escalante, T, Teresa Escalante (337914), Herrera, Cristina, Calvete, Juan J., Sussan Nourshargh, José María Gutiérrez (62868), Escalante Muñoz, Teresa, Herrera Arias, Cristina, Fox, JW, Fox, Jay W., Gutiérrez, José María   +47 more
core   +1 more source

Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis [PDF]

, 2008
Aims/hypothesisThis study examined whether the capsule which encases islets of Langerhans in the NOD mouse pancreas represents a specialised extracellular matrix (ECM) or basement membrane that protects islets from autoimmune attack ...
Rodgers, R., Irving-Rodgers, H., Rodgers, Raymond, Irving-Rodgers, Helen, Sado, Yoshikazu, Ziolkowski, A., Ziolkowski, Andrew, H. F. Irving-Rodgers, C. J. Simeonovic, R. J. Rodgers, Rodgers, Ray, Sado, Y., Parish, Christopher, Ninomiya, Yoshifumi, C. R. Parish, Simeonovic, C., Ninomiya, Y., Y. Sado, A. F. Ziolkowski, Y. Ninomiya, Simeonovic, Charmaine, Parish, C., Irving-Rodgers, H.F.   +22 more
core   +1 more source

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration.

Cell Reports, 2017
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood.
Jian Song, Xueli Zhang, Konrad Buscher, Ying Wang, Huiyu Wang, Jacopo Di Russo, Li-Xia Li, Stefan Lütke-Enking, A. Zarbock, Anika Stadtmann, Paul Striewski, Benedikt Wirth, I. Kuzmanov, H. Wiendl, Dörte Schulte, D. Vestweber, L. Sorokin   +16 more
semanticscholar   +1 more source

Basement membrane and stroke

Journal of Cerebral Blood Flow and Metabolism, 2018
Located at the interface of the circulation system and the CNS, the basement membrane (BM) is well positioned to regulate blood–brain barrier (BBB) integrity.
Yao Yao
semanticscholar   +1 more source