Results 51 to 60 of about 3,706,301 (294)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Disease Models & Mechanisms, 2016
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects.
Frances E. Jones, Matthew A. Bailey, Lydia S. Murray, Yinhui Lu, Sarah McNeilly, Ursula Schlötzer-Schrehardt, Rachel Lennon, Yoshikazu Sado, David G. Brownstein, John J. Mullins, Karl E. Kadler, Tom Van Agtmael   +11 more
doaj   +1 more source

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Nature Communications, 2021
The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional ...
Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, Hironobu Fujiwara   +7 more
doaj   +1 more source

Clinical Significance of Zero-Time Renal Transplant Biopsies and Thin Glomerular Basement Membranes in Zero-Time Renal Transplant Biopsies

Acta Clinica Croatica, 2021
Aim. To investigate morphological findings of zero-time biopsies analyzed at the Department of Nephropathology and Electron Microscopy, Dubrava University Hospital, Zagreb. Materials and methods.
Petar Šenjug, Matija Horaček, Bojana Maksimović, Ksenija Vučur, Ivica Horvatić, Nikola Zagorec, Mladen Knotek, Danica Galešić Ljubanović   +7 more
doaj   +1 more source

Basement membrane mechanics shape development: Lesson from the fly

Matrix Biology, 2018
Basement membrane plays a foundational role in the structure and maintenance of many tissues throughout the animal kingdom. In addition to signaling to cells through cell-surface receptors, basement membrane directly influences the development and ...
William Ramos-Lewis, Andrea Page-McCaw
semanticscholar   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An animal component-free bioprocess for synthesizing 3D human matrix scaffolds using mesenchymal stromal cells

Frontiers in Cell and Developmental Biology
IntroductionThe basement membrane is a specialized extracellular matrix that compartmentalizes epithelial and endothelial tissues and provides essential structural and signaling cues for tissue organization.
Shaianne N. Stein, Shaianne N. Stein, Lorena R. Braid, Lorena R. Braid   +3 more
doaj   +1 more source

Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice

Science Translational Medicine, 2017
Transgenic expression of two small linker proteins restores muscle function and prolongs life span in a mouse model of LAMA2-related muscular dystrophy.
J. Reinhard, Shuo Lin, K. McKee, S. Meinen, S. Crosson, M. Sury, S. Hobbs, Geraldine Maier, P. Yurchenco, Markus A. Rüegg   +9 more
semanticscholar   +1 more source

Difficulties in differentiating thin basement membrane disease from Alport syndrome

, 2016
We examined a group of 83 patients (57 children and 26 adults) with thin basement membrane disease and 17 patients with Alport syndrome. We compared the clinical data and, above all, the morphological patterns of both disease entities, with particular ...
Aldona Woźniak, Wiesława Salwa-Żurawska, Jakub Żurawski, Paweł Burchardt, Marcin Grochowalski, Monika Seget, Jerzy Moczko   +6 more
core   +1 more source