Results 111 to 120 of about 114,819 (309)

The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells

Frontiers in Immunology
IntroductionThe Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of transcription (STAT).
Remo Poto, Remo Poto, Remo Poto, Leonardo Cristinziano, Leonardo Cristinziano, Leonardo Cristinziano, Gjada Criscuolo, Gjada Criscuolo, Gjada Criscuolo, Caterina Strisciuglio, Francesco Palestra, Francesco Palestra, Gianluca Lagnese, Gianluca Lagnese, Antonio Di Salvatore, Antonio Di Salvatore, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Giuseppe Spadaro, Giuseppe Spadaro, Giuseppe Spadaro, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +30 more
doaj   +1 more source

Intranasal administration of allergen increases specific IgE whereas intranasal omalizumab does not increase serum IgE levels : a pilot study [PDF]

, 2018
Background: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases in IgE antibody levels. Objective: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab ...
Bischoff, Cameron, Chan, Chanez, Christianson, Chu, Dema, Eckl-Dorna, Egger, Egger, Gevaert, Ghetie, Gieras, Hauswirth, Hayashi, Humbert, Ishizaka, Jabara, Jardieu, Kaplan, Katona, KleinJan, Laffer, Lawrence, Lowe, Lupinek, MacGlashan, Mizuma, Naclerio, Nakamura, Narayanan, Niederberger, Noga, Noga, Ota, Platts-Mills, Steinberger, Stokes, Valent   +38 more
core   +1 more source

Age‐related local versus systemic early phase wound healing dynamics following free gingival graft harvest

Journal of Periodontology, EarlyView.
Abstract Background Free palatal gingival grafts (FGG) are commonly harvested during mucogingival procedures. The present study investigates age‐related local and systemic early secondary wound healing outcomes, following FGG harvest in a rat model. Methods A 4.2 mm diameter defect was created in the palate of 24 younger (2 m) and 24 older (6 m) Wistar
Maayan Atzmon‐Shavit, Marilena Vered, Michael Saminsky, Liat Chaushu   +3 more
wiley   +1 more source

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

The Role of Artificial Intelligence in Modern Allergology: A Review of Applications in Diagnosis, Prediction, and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Artificial Intelligence is rapidly transforming allergology by enhancing diagnosis, risk prediction, automation, patient communication, education, and therapy development. Machine learning approaches, including convolutional neural networks, recurrent architectures, and transformer‐based models, enable analysis of complex datasets from ...
Sebastian Seurig, Stephan Traidl, Sonja Mathes   +2 more
wiley   +1 more source

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

Allergology International, 2013
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus.
Susumu Nakae, Hideaki Morita, Tatsukuni Ohno, Ken Arae, Kenji Matsumoto, Hirohisa Saito   +5 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

A cytophotometric analysis of anterior pituitary changes in rats exposed to reduced pressure [PDF]

Adaptive cytochemical responses of hormone producing cells of rat anterior pituitary following exposure to simulated high ...
Anthony, A., Rockwell, K.
core   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Corrigendum: IL-3 produced by T cells is crucial for basophil extravasation in hapten- induced allergic contact dermatitis

Frontiers in Immunology, 2023
Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam, Pierre Meyer, Eric Flatter, Marie-Christine Birling, Jagadeesh Bayry, Jagadeesh Bayry, Mei Li   +10 more
doaj   +1 more source