Results 91 to 100 of about 114,819 (309)

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Basophils and Eosinophils in Nematode Infections

Frontiers in Immunology, 2020
Helminths remain one of the most prolific pathogens in the world. Following infection helminths interact with various epithelial cell surfaces, including skin, lung, and gut.
Kazushige Obata-Ninomiya, Phillip P. Domeier, Steven F. Ziegler, Steven F. Ziegler   +3 more
doaj   +1 more source

THE HEMIC BASOPHIL [PDF]

Journal of Experimental Medicine, 1920
1. The basophilic granule of blood and marrow cells does not show the brown color reaction with benzidine solutions that is characteristic of the neutrophilic and eosinophilic granules. It differs from these types also in other important microchemical and physical particulars. 2.
openaire   +2 more sources

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model

Frontiers in Immunology
BackgroundAtopic dermatitis (AD), a prevalent inflammatory skin disease affecting 10%-20% of the population, is linked to the development of asthma through atopic march (AM).
Xu Li, Zizhuo Li, Mindan Tang, Kaoyuan Zhang, Kaoyuan Zhang, Kaoyuan Zhang, Ting Yang, Weilong Zhong, Bo Yu, Bo Yu, Bo Yu, Fang Wang, Xia Dou, Xia Dou, Xia Dou   +14 more
doaj   +1 more source

Innate type 2 immunity in helminth infection is induced redundantly and acts autonomously following CD11c+ cell depletion [PDF]

, 2012
Infection with gastrointestinal helminths generates a dominant type 2 response among both adaptive (Th2) and innate (macrophage, eosinophil, and innate lymphoid) immune cell types.
Garbi, Natalio, Harcus, Yvonne, Hämmerling, Günter J, Macdonald, Andrew S, Maizels, Rick M, Smith, Katherine A   +5 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

A comparison between two different in vitro basophil activation tests for gluten- and cow's milk protein sensitivity in irritable bowel syndrome (IBS)-like patients. [PDF]

, 2012
Background: The diagnosis of food hypersensitivity (FH) in adult patients with gastrointestinal symptoms, beyond the immediate IgE-mediated clinical manifestations, is very often difficult.
Barrale, M, Brusca, I, CARROCCIO, Antonio, D'ALCAMO, Alberto, Iacono, G, La Chiusa, SM, MANSUETO, Pasquale, SEIDITA, Aurelio, SORESI, Maurizio, Sprini, D.   +9 more
core   +1 more source

Optimizing Cell Sorting Performance: A Comparative Study Utilizing Spectral Flow Cytometry

Cytometry Part A, EarlyView.
Strategy for the Evaluation of Multi‐way Sort Performance. ABSTRACT The introduction of full spectral technology in flow cytometry has facilitated access to an increasing number of markers to define cell subsets with higher precision. Cell sorting has a unique advantage to combine high throughput single cell analysis and recovery of rare live single ...
Jarina Pena DaMata, Randall Johnson, Iyadh Douagi   +2 more
wiley   +1 more source

The host immune response to gastrointestinal nematode infection in sheep [PDF]

, 2015
non peer reviewedGastrointestinal nematode infection represents a major threat to the health, welfare and productivity of sheep populations worldwide. Infected lambs have a reduced ability to absorb nutrients from the gastrointestinal tract, resulting in
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core   +1 more source